D Cruze Lawrence, Sundaram Sandhya, Iyer Shruti, Ganesh Krishnamurthy
Department of Pathology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.
Department of MBBS Student, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.
Asian J Neurosurg. 2021 Feb 23;16(1):183-186. doi: 10.4103/ajns.AJNS_315_20. eCollection 2021 Jan-Mar.
Astroblastoma is a very rare glial tumor derived from astroblasts. It has been controversial in terms of its features and diagnosis. The objective of this report is to present the findings of the high-grade astroblastoma with a good prognosis in a 21-year-old female who presented to us with diplopia and headache. While imaging led to the foremost differentials of pleomorphic xanthoastrocytoma and Ganglioglioma which are low-grade neoplasms, the final diagnosis was established on microscopy and immunohistochemistry after excision. Treatment protocol included surgery with postoperative radiotherapy and chemotherapy. Due to controversial and limited literature, this tumor poses difficulties in diagnosis and management. This is a rare, successfully managed case of astroblastoma with a positive outcome 5 years after the diagnosis was established. In this case report, we review the steps of diagnosis, the differentials, the pathological and histological features, and the management of this rare entity.
成星形细胞瘤是一种非常罕见的源自成星形细胞的神经胶质瘤。其特征和诊断一直存在争议。本报告的目的是介绍一名21岁女性高级别成星形细胞瘤的病例，该患者因复视和头痛前来就诊，预后良好。影像学检查最初提示的鉴别诊断为多形性黄色星形细胞瘤和节细胞胶质瘤，二者均为低级别肿瘤，但最终诊断是在切除术后通过显微镜检查和免疫组织化学确定的。治疗方案包括手术，术后进行放疗和化疗。由于相关文献存在争议且有限，这种肿瘤在诊断和治疗方面存在困难。这是一例罕见的、成功治疗的成星形细胞瘤病例，确诊5年后预后良好。在本病例报告中，我们回顾了该罕见疾病的诊断步骤、鉴别诊断、病理和组织学特征以及治疗方法。
