成星形细胞瘤患者的护理模式与治疗结果：一项国家癌症数据库分析
Patterns of care and treatment outcomes of patients with astroblastoma: a National Cancer Database analysis.
作者信息
Merfeld Emily C, Dahiya Sonika, Perkins Stephanie M
机构信息
Department of Radiation Oncology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110 USA.
Department of Pathology & Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110 USA.
出版信息
CNS Oncol. 2018 Apr;7(2):CNS13. doi: 10.2217/cns-2017-0038. Epub 2018 Apr 30.
AIM
To evaluate the use of chemotherapy and radiation, and their outcomes for patients with astroblastoma.
PATIENTS & METHODS: This is a retrospective review of patients extracted from the National Cancer Database. We investigated overall survival (OS) using Kaplan-Meier curves. Cox proportional hazards models were used to correlate OS with risk variables and treatments.
RESULTS
OS at 5 years was 79.5%. Patients with high-grade tumors were more likely to receive chemotherapy and radiation. Patients with high-grade astroblastoma who did not receive adjuvant radiation had poor survival.
CONCLUSION
Patients with astroblastoma should be treated with curative intent. Radiation is likely beneficial in high-grade astroblastoma. The exact role of radiation and chemotherapy following surgical resection warrant further investigation.
目的
评估化疗和放疗的应用及其在成星形细胞瘤患者中的治疗效果。
患者与方法
这是一项对从国家癌症数据库中提取的患者进行的回顾性研究。我们使用Kaplan-Meier曲线研究总生存期（OS）。采用Cox比例风险模型将总生存期与风险变量及治疗方法进行关联分析。
结果
5年总生存率为79.5%。高级别肿瘤患者更有可能接受化疗和放疗。未接受辅助放疗的高级别成星形细胞瘤患者生存率较差。
结论
成星形细胞瘤患者应以治愈为目的进行治疗。放疗可能对高级别成星形细胞瘤有益。手术切除后放疗和化疗的确切作用有待进一步研究。
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