Bochner C J, Williams J, Castro L, Medearis A, Hobel C J, Wade M
Department of Obstetrics and Gynecology, Cedars Sinai Medical Center, Los Angeles, CA 90048.
Am J Obstet Gynecol. 1988 Sep;159(3):550-4. doi: 10.1016/s0002-9378(88)80005-x.
Postterm antenatal fetal surveillance has traditionally begun at 42 completed weeks of gestation. However, recent data have shown that a significant percentage of cases of perinatal asphyxia occurs between 40 and 42 weeks of gestation. We compared the perinatal outcome of fetuses with antenatal surveillance beginning at 41 weeks to those starting at 42 weeks of gestation. The study groups consisted of 908 patients who began antenatal testing at 41 weeks and 352 who began testing at 42 weeks. Antenatal testing consisted of twice-weekly amniotic fluid assessments and nonstress tests (including evaluation for late and variable decelerations). Between 41 and 42 weeks, the group whose testing started at 41 weeks had an overall incidence of intrapartum fetal distress of 2.7%, no stillbirths, and no infants with major neonatal morbidity. Patients without antenatal testing who delivered between 41 to 42 weeks did not have a significantly increased incidence of fetal distress (3.3%; p = 0.07). However, this group had a significantly increased incidence of adverse outcomes (p less than 0.05), including three stillbirths and seven cases of major neonatal morbidity. Beyond 42 weeks, the group whose testing started at 41 weeks had a 2.3% overall incidence of fetal distress. This was significantly less (p less than 0.01) than the group whose testing started at 42 weeks (5.6%). Neither of the groups had any stillbirths or infants with major neonatal morbidity. These findings suggest that starting antenatal testing at 41 weeks of gestation may result in decreased postterm perinatal mortality and morbidity as well as a decreased incidence of intrapartum fetal distress.
过期产儿产前胎儿监测传统上始于妊娠满42周。然而,最近的数据表明,相当比例的围产期窒息病例发生在妊娠40至42周之间。我们比较了产前监测从41周开始的胎儿与从42周开始的胎儿的围产期结局。研究组包括908例在41周开始产前检查的患者和352例在42周开始检查的患者。产前检查包括每周两次的羊水评估和无应激试验(包括评估晚期减速和变异减速)。在41至42周之间,从41周开始检查的组产时胎儿窘迫的总发生率为2.7%,无死产,也无患有严重新生儿疾病的婴儿。在41至42周之间分娩且未进行产前检查的患者,胎儿窘迫的发生率没有显著增加(3.3%;p = 0.07)。然而,该组不良结局的发生率显著增加(p小于0.05),包括3例死产和7例严重新生儿疾病。超过42周时,从41周开始检查的组胎儿窘迫的总发生率为2.3%。这显著低于(p小于0.01)从42周开始检查的组(5.6%)。两组均无死产或患有严重新生儿疾病的婴儿。这些发现表明,在妊娠41周开始产前检查可能会降低过期产儿的围产期死亡率和发病率,以及产时胎儿窘迫的发生率。