Escuela de Medicina, Universidad de Santiago de Chile (USACH), Santiago, Chile; Departamento de Infectología, Hospital Barros Luco, Santiago, Chile. Adress: Escuela de Medicina, Universidad de Santiago de Chile, Avenida Libertador Bernardo O'Higgins 3363, Estación Central, Santiago, Chile. Email:
Escuela de Medicina, Universidad de Santiago de Chile (USACH), Santiago, Chile. ORCID: 0000-0002-5715-9755.
Medwave. 2021 May 25;21(4):e8198. doi: 10.5867/medwave.2021.04.8198.
Coronavirus disease 2019 (COVID-19), caused by the SARS-CoV-2 virus discovered in December 2019 in Wuhan, China, has had an enormous impact on public health worldwide due to its rapid spread and pandemic behavior, challenges in its control and mitigation, and few therapeutic alternatives. In this review, we summarize the pathophysiological mechanisms, clinical presentation, and diagnostic techniques. In addition, the main lineages and the different strategies for disease prevention are reviewed, with emphasis on the development of vaccines and their different platforms. Finally, some of the currently available therapeutic strategies are summarized. Throughout the article, we point out the current knowns and unknowns at the time of writing this article.
2019 年冠状病毒病（COVID-19），由 2019 年 12 月在中国武汉发现的 SARS-CoV-2 病毒引起，由于其快速传播和大流行行为、控制和缓解方面的挑战以及治疗方法选择有限，对全球公共卫生造成了巨大影响。在这篇综述中，我们总结了病理生理学机制、临床表现和诊断技术。此外，还回顾了主要谱系和疾病预防的不同策略，重点介绍了疫苗的开发及其不同平台。最后，总结了一些目前可用的治疗策略。在整篇文章中，我们指出了在撰写本文时的已知和未知情况。
