Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Guwahati, Assam, India; Department of Biomedical Engineering, Indian Institute of Technology (IIT), Ropar, Punjab, India.
Department of Pharmacology, Goa College of Pharmacy, Goa, India.
Biomed Pharmacother. 2021 May;137:111254. doi: 10.1016/j.biopha.2021.111254. Epub 2021 Jan 28.
The SARS-CoV-2, previously called a novel coronavirus, that broke out in the Wuhan city of China caused a significant number of morbidity and mortality in the world. It is spreading at peak levels since the first case reported and the need for vaccines is in immense demand globally. Numerous treatment and vaccination strategies that were previously employed for other pathogens including coronaviruses are now being been adopted to guide the formulation of new SARS-CoV-2 vaccines. Several vaccine targets can be utilized for the development of the SARS-CoV-2 vaccine. In this review, we highlighted the potential of various antigenic targets and other modes for formulating an effective vaccine against SARS-CoV-2. There are a varying number of challenges encountered during developing the most effective vaccines, and measures for tackling such challenges will assist in fast pace development of vaccines. This review will give a concise overview of various aspects of the vaccine development process against SARS-CoV-2, including 1) potential antigen targets 2) different vaccination strategies from conventional to novel platforms, 3) ongoing clinical trials, 4) varying challenges encountered during developing the most effective vaccine and the futuristic approaches.
在中国武汉市爆发的新型冠状病毒（SARS-CoV-2），以前被称为新型冠状病毒，在世界范围内造成了大量的发病率和死亡率。自首例病例报告以来，该病毒的传播处于高峰期，全球对疫苗的需求巨大。以前用于包括冠状病毒在内的其他病原体的许多治疗和疫苗接种策略现在正在被采用，以指导新的 SARS-CoV-2 疫苗的制定。可以利用多种疫苗靶点来开发 SARS-CoV-2 疫苗。在这篇综述中，我们强调了各种抗原靶点和其他模式在制定针对 SARS-CoV-2 的有效疫苗方面的潜力。在开发最有效的疫苗时，会遇到许多不同的挑战，而应对这些挑战的措施将有助于加快疫苗的开发速度。本文综述了针对 SARS-CoV-2 的疫苗开发过程的各个方面，包括 1）潜在的抗原靶点 2）从传统到新型平台的不同疫苗接种策略，3）正在进行的临床试验，4）在开发最有效的疫苗时遇到的各种挑战，以及未来的方法。
