Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20090, Milan, Italy.
Otorhinolaryngology-Head & Neck Surgery Unit, Humanitas Clinical and Research Center-IRCCS, via Manzoni 56, Rozzano, 20089, Milan, Italy.
Eur Arch Otorhinolaryngol. 2022 Jan;279(1):527-531. doi: 10.1007/s00405-021-06964-6. Epub 2021 Jul 2.
To underline discrepancies between the Union for International Cancer Control (UICC) and the American Joint Committee on Cancer (AJCC) Tumor-Node-Metastasis (TNM) classifications in oral cavity cancer.
Comparison between the UICC and AJCC TNM classifications of oral cavity cancer in their 8th editions and following versions.
The most important update was the introduction of the depth of infiltration (DOI), which reflects the proximity of the tumor to the underlying lymphovascular tissues and was associated to the presence of nodal metastases. Since the first publication of the 8th edition of the AJCC Cancer Staging Manual on March 30, 2017, two further versions have been published, while the UICC TNM classification was left unchanged until a document containing modifications to the 8th edition of the UICC TNM Classification of Malignant Tumours was published online on October 6, 2020.
Different versions of the TNM classification can be confounding for the scientific community. Citing the 8th edition of the UICC TNM Classification of Malignant Tumours or the AJCC Cancer Staging Manual without specifying the precise version used for classification may be insufficient. Clinicians and researchers are invited to always refer to the latest update of each classification.
强调国际癌症控制联盟（UICC）与美国癌症联合委员会（AJCC）口腔癌肿瘤-淋巴结-转移（TNM）分类之间的差异。
比较口腔癌第 8 版及后续版本的 UICC 和 AJCC TNM 分类。
最重要的更新是引入了浸润深度（DOI），它反映了肿瘤与下方淋巴血管组织的接近程度，并与淋巴结转移的存在相关。自 2017 年 3 月 30 日 AJCC 癌症分期手册第 8 版首次出版以来，已经发布了两个后续版本，而 UICC TNM 分类直到 2020 年 10 月 6 日在线发布包含对第 8 版 UICC 恶性肿瘤 TNM 分类修改的文件才保持不变。
TNM 分类的不同版本可能会令科学界感到困惑。仅引用第 8 版 UICC 恶性肿瘤 TNM 分类或 AJCC 癌症分期手册，而不指定用于分类的确切版本可能是不够的。临床医生和研究人员被邀请始终参考每个分类的最新更新。
