Chong Wai Hong, Leong Sim Siong, Lim JitKang
School of Chemical Engineering, Universiti Sains Malaysia, Penang, Malaysia.
Department of Petrochemical Engineering, Faculty of Engineering and Green Technology, Universiti Tunku Abdul Rahman, Kampar, Perak, Malaysia.
Electrophoresis. 2021 Nov;42(21-22):2303-2328. doi: 10.1002/elps.202100081. Epub 2021 Jul 28.
Combining both device and particle designs are the essential concepts to be considered in magnetophoretic system development. Researcher efforts are often dedicated to only one of these design aspects and neglecting the interplay between them. Herein, to bring out importance of the idea of integration between device and particle, we reviewed the working principle of magnetophoretic system (includes both device and particle design concepts). Since, the magnetophoretic force is influenced by both field gradient and magnetization volume, hence, accurate prediction of the magnetophoretic force is relying on the availability of information on both parameters. In device design, we focus on the different strategies used to create localized high-field gradient. For particle design, we emphasize on the scaling between hydrodynamic size and magnetization volume. Moreover, we also briefly discussed the importance of magnetoshape anisotropy related to particle design aspect of magnetophoretic systems. Next, we illustrated the need for integration between device and particle design using microscale applications of magnetophoretic systems, include magnetic tweezers and microfluidic systems, as our working example. On the basis of our discussion, we highlighted several promising examples of microscale magnetophoretic systems which greatly utilized the interplay between device and particle design. Further, we concluded the review with several factors that possibly resulted in the lack of research efforts related to device and particle design integration.
结合设备和粒子设计是磁泳系统开发中需要考虑的基本概念。研究人员的精力往往只专注于这些设计方面中的一个，而忽略了它们之间的相互作用。在此，为了凸显设备与粒子一体化理念的重要性，我们回顾了磁泳系统的工作原理（包括设备和粒子设计概念）。由于磁泳力受场梯度和磁化体积两者影响，因此，磁泳力的准确预测依赖于这两个参数信息的可得性。在设备设计方面，我们关注用于产生局部高场梯度的不同策略。对于粒子设计，我们强调流体动力学尺寸与磁化体积之间的比例关系。此外，我们还简要讨论了与磁泳系统粒子设计方面相关的磁形状各向异性的重要性。接下来，我们以磁泳系统的微观应用，包括磁性镊子和微流体系统为例，来说明设备与粒子设计一体化的必要性。基于我们的讨论，我们重点介绍了几个充分利用设备与粒子设计相互作用的微观磁泳系统的成功案例。此外，我们在综述结尾总结了可能导致在设备与粒子设计一体化方面缺乏研究工作的几个因素。
