CNRS, UMR8104, Paris, France.
Inserm, U1016, Institut Cochin, Paris, France.
C R Biol. 2021 Jul 2;344(2):127-143. doi: 10.5802/crbiol.56.
Neisseria meningitidis (meningococcus) is a Gram-negative bacterium responsible for two devastating forms of invasive diseases: purpura fulminans and meningitis. Since the first description of the epidemic nature of the illness at the dawn of the nineteenth century, the scientific knowledge of meningococcal infection has increased greatly. Major advances have been made in the management of the disease with the advent of antimicrobial therapy and the implementation of meningococcal vaccines. More recently, an extensive knowledge has been accumulated on meningococcal interaction with its human host, revealing key processes involved in disease progression and new promising therapeutic approaches.
脑膜炎奈瑟菌（脑膜炎球菌）是一种革兰氏阴性细菌，可引起两种具有破坏性的侵袭性疾病：暴发性紫癜和脑膜炎。自 19 世纪初首次描述这种疾病的流行性质以来，人们对脑膜炎奈瑟菌感染的科学认识有了很大的提高。随着抗菌治疗的出现和脑膜炎球菌疫苗的应用，该疾病的治疗取得了重大进展。最近，人们对脑膜炎奈瑟菌与人宿主的相互作用有了广泛的了解，揭示了疾病进展过程中的关键步骤和新的有前途的治疗方法。
