Department of Clinical Laboratory, Peking University People's Hospital, 11 Xizhimen South Street, Xicheng District, Beijing 100044, China.
Systemic Autoimmunity Branch, Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, 10 Center Drive, 12N248C, Bethesda, MD 20892-1930, USA.
Rheum Dis Clin North Am. 2021 Aug;47(3):317-333. doi: 10.1016/j.rdc.2021.04.002. Epub 2021 Jun 9.
The recent identifications of a subset of proinflammatory neutrophils, low-density granulocytes, and their ability to readily form neutrophil extracellular traps led to a resurgence of interest in neutrophil dysregulation in the pathogenesis of systemic lupus erythematosus (SLE). This article presents an overview on how neutrophil dysregulation modulates the innate and adaptive immune responses in SLE and their putative roles in disease pathogenesis. The therapeutic potential of targeting this pathogenic process in the treatment of SLE is also discussed.
最近，人们发现了一组促炎中性粒细胞、低密度粒细胞，并发现它们能够轻易形成中性粒细胞细胞外陷阱，这使得人们对系统性红斑狼疮 (SLE) 发病机制中中性粒细胞失调重新产生了兴趣。本文概述了中性粒细胞失调如何调节 SLE 中的先天和适应性免疫反应及其在疾病发病机制中的潜在作用。还讨论了针对该致病过程治疗 SLE 的治疗潜力。
