Molecular Oncology Group, Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park, Macclesfield, Cheshire, UK.
Medical Oncology, The Christie NHS Foundation Trust, Manchester, UK.
Nat Commun. 2021 Jul 2;12(1):4098. doi: 10.1038/s41467-021-24343-x.
Tumor infiltration by T cells is paramount for effective anti-cancer immune responses. We hypothesized that the T cell receptor (TCR) repertoire of tumor infiltrating T lymphocytes could therefore be indicative of the functional state of these cells and determine disease course at different stages in cancer progression. Here we show that the diversity of the TCR of tumor infiltrating T cell at baseline is prognostic in various cancers, whereas the TCR clonality of T cell infiltrating metastatic melanoma pre-treatment is predictive for activity and efficacy of PD1 blockade immunotherapy.
T 细胞浸润肿瘤对于有效的抗肿瘤免疫反应至关重要。我们假设，肿瘤浸润 T 淋巴细胞的 T 细胞受体（TCR）谱因此可以表明这些细胞的功能状态，并在癌症进展的不同阶段决定疾病进程。在这里，我们表明，基线时肿瘤浸润 T 细胞 TCR 的多样性在各种癌症中具有预后意义，而浸润转移性黑色素瘤的 T 细胞 TCR 的克隆性在 PD1 阻断免疫治疗的活性和疗效方面具有预测性。
