Department of Ophthalmology, School of Medicine, Atakent Education and Research Hospital, Acibadem University, Turgut Ozal Blvd. No:16, Kucukcekmece, 34303, Istanbul, Turkey.
Department of Otorhinolaryngology, Eregli State Hospital, Toros Mah. Yurt Cad. No: 13, Eregli, 42000, Konya, Turkey.
Sci Rep. 2021 Jul 2;11(1):13782. doi: 10.1038/s41598-021-93233-5.
To determine the short-term effect of topically administered ocular moxifloxacin on conjunctival and nasal bacterial mucosal flora. The study included 20 patients with newly diagnosed age-related macular degeneration. Each patient's diseased eye was selected as the treatment eye and the fellow eye was selected as the control eye. All treatment eyes constituted the treatment group and all controls eyes constituted the control group. All patients received intravitreal injection of ranibizumab. Cultures were obtained from the inferior conjunctival fornix and the nostrils in all patients. Patients were instructed to administer moxifloxacin eye drops to the treatment eye 4 times daily for 1 week. The patients were instructed to come for a follow-up exam 1 week post intravitreal injection. The bacterial culture positivity rate and the bacteria isolated from the conjunctiva and nostrils were recorded in the 2 groups before and after use of topical ocular moxifloxacin. Mean age of the patients (12 female and 8 male) was 64.9 years. Before use of topical ocular moxifloxacin the conjunctival and nasal culture positivity rates in the treatment group were both 100%, versus 90% and 95%, respectively, in the control group. At the follow-up exam the conjunctival and nasal mucosa culture positivity rates in the treatment group decreased to 20% (4/20) and 30% (6/20), respectively (P < 0.001), versus 85% (17/20) and 80% (16/20), respectively, in the control group (P = 0.68 and P = 0.72 for conjunctival and nasal). This is the first study to show that moxifloxacin applied to the ocular surface topically has a significant effect on nasal flora. Daily administration of topical ocular moxifloxacin for 1 week significantly reduces the nasal bacterial flora in addition to conjunctival flora.
观察局部应用眼部莫西沙星对结膜和鼻腔黏膜细菌菌群的短期影响。
本研究纳入了 20 例新诊断为年龄相关性黄斑变性的患者。每位患者的患眼被选为治疗眼，对侧眼被选为对照眼。所有治疗眼构成治疗组，所有对照眼构成对照组。所有患者均接受了玻璃体内注射雷珠单抗。所有患者均从下结膜穹窿和鼻腔采集培养物。指导患者每日向治疗眼滴用莫西沙星滴眼液 4 次，持续 1 周。患者在玻璃体内注射后 1 周接受随访检查。记录两组患者在使用局部眼部莫西沙星前后结膜和鼻腔分离的细菌培养阳性率和细菌种类。
患者（12 名女性和 8 名男性）的平均年龄为 64.9 岁。在使用局部眼部莫西沙星之前，治疗组的结膜和鼻腔培养阳性率均为 100%，而对照组分别为 90%和 95%。在随访检查时，治疗组的结膜和鼻腔黏膜培养阳性率分别降至 20%（20 例中的 4 例）和 30%（20 例中的 6 例）（P < 0.001），而对照组分别为 85%（20 例中的 17 例）和 80%（20 例中的 16 例）（P = 0.68 和 P = 0.72，用于结膜和鼻腔）。这是第一项表明局部应用眼部莫西沙星对鼻腔菌群有显著影响的研究。
局部使用眼部莫西沙星 1 周可显著降低结膜菌群，此外还可显著降低鼻腔菌群。
