Department of Pediatric Surgery, University of Leipzig, Liebigstraße 20 a, 04103, Leipzig, Germany.
Department of Pediatrics, University of Lübeck, Lübeck, Germany.
Sci Rep. 2021 Jul 2;11(1):13777. doi: 10.1038/s41598-021-93195-8.
Necrotizing enterocolitis (NEC) and focal intestinal perforation (FIP) are two of the most common emergencies of the gastrointestinal tract in preterm infants with very low birth weight (VLBW, birth weight < 1500 g). Identification of risk factors among these children is crucial for earlier diagnosis and prompt intervention. In this study, we investigated a relationship between ABO blood groups and the risk for surgical NEC/FIP. We genotyped the ABO locus (rs8176746 and rs8176719) in VLBW infants enrolled in a prospective, population-based cohort study of the German Neonatal Network (GNN). Of the 10,257 VLBW infants, 441 (4.3%) had surgical NEC/FIP. In univariate analyses, the blood group AB was more prevalent in VLBW infants with surgical NEC/FIP compared to non-AB blood groups (OR 1.51, 95% CI 1.07-2.13, p = 0.017; absolute risk difference 2.01%, 95% CI 0.06-3.96%). The association between blood group AB and surgical NEC/FIP was observed in a multivariable logistic regression model (OR of 1.58, 95% CI 1.10-2.26, p = 0.013) as well. In summary, our study suggests that the risk of surgical NEC and FIP is higher in patients with blood group AB and lower in those having non-AB blood groups.
新生儿坏死性小肠结肠炎 (NEC) 和局灶性肠穿孔 (FIP) 是极低出生体重儿 (VLBW，出生体重 < 1500 g) 胃肠道最常见的两种急症。识别这些儿童的危险因素对于早期诊断和及时干预至关重要。在这项研究中，我们研究了 ABO 血型与手术 NEC/FIP 风险之间的关系。我们对德国新生儿网络 (GNN) 前瞻性、基于人群的队列研究中纳入的 VLBW 婴儿的 ABO 基因座 (rs8176746 和 rs8176719) 进行了基因分型。在 10257 名 VLBW 婴儿中，有 441 名 (4.3%) 患有手术 NEC/FIP。在单变量分析中，与非 AB 血型组相比，手术 NEC/FIP 的 VLBW 婴儿中 AB 血型更为常见 (OR 1.51，95%CI 1.07-2.13，p=0.017；绝对风险差异 2.01%，95%CI 0.06-3.96%)。多变量逻辑回归模型也观察到 AB 血型与手术 NEC/FIP 之间存在关联 (OR 为 1.58，95%CI 1.10-2.26，p=0.013)。总之，我们的研究表明，AB 血型患者发生手术 NEC 和 FIP 的风险较高，而非 AB 血型患者的风险较低。
