From the Department of Cardiology, University of Groningen, University Medical Center Groningen, the Netherlands (H.E.G., L.E.V.S., M.A.S., E.L., J.C.K., P.v.d.H.).
University of Antioquia, School of Medicine, Medellín, Colombia (L.E.V.S.).
Arterioscler Thromb Vasc Biol. 2020 Mar;40(3):830-838. doi: 10.1161/ATVBAHA.119.313658. Epub 2020 Jan 23.
To determine the spectrum of phenotypes linked to the ABO blood group system, using genetic determinants of the ABO blood group system. Approach and Results: We assessed the risk of 41 health and disease outcomes, and 36 linear traits associated with the ABO blood group system in the UK Biobank cohort. A total of 406 755 unrelated individuals were included in this study. Blood groups A, B, and O were determined based on allele combinations of previously established single-nucleotide polymorphisms rs8176746, rs8176719 in the ABO gene. Group AB was excluded because of its relative small sample size. Overall, 187 387 (46%) were male with a mean (SD) age of 57±8.1 years and a median total exposure of 64 person-years (interquartile range, 57-70). Of 406 755 individuals, 182 621 (44.9%) participants had blood group O, 182 786 (44.9%) had blood group A, and 41 348 (10.2%) had blood group B. ABO blood groups were associated with 11 health and disease outcomes (<2.19×10). ABO blood groups were primarily associated with cardiovascular outcomes. Compared with individuals with blood group O, blood groups A and B were associated with increased odds of up to 1.56 (95% CI, 1.43-1.69) for thromboembolic events and decreased odds for hypertension (0.94 [95% CI, 0.92-0.97]).
The ABO blood group system is associated with several parameters of healthy aging and disease development. Knowledge of ABO blood groups might be of interest for more personalized approaches towards health maintenance and the prevention of diseases.
利用 ABO 血型系统的遗传决定因素，确定与 ABO 血型系统相关的表型谱。
我们评估了英国生物库队列中与 ABO 血型系统相关的 41 种健康和疾病结果以及 36 种线性特征的风险。本研究共纳入 406755 名无亲缘关系的个体。血型 A、B 和 O 是根据先前建立的 ABO 基因中的单核苷酸多态性 rs8176746 和 rs8176719 的等位基因组合确定的。由于 AB 组的样本量相对较小，因此排除了 AB 组。总体而言，187387 名（46%）为男性，平均（SD）年龄为 57±8.1 岁，中位数总暴露时间为 64 人年（四分位间距，57-70）。在 406755 名个体中，182621 名（44.9%）参与者为 O 型血，182786 名（44.9%）为 A 型血，41348 名（10.2%）为 B 型血。ABO 血型与 11 种健康和疾病结果相关（<2.19×10）。ABO 血型主要与心血管结果相关。与 O 型血个体相比，A 型和 B 型血与血栓栓塞事件的几率增加了 1.56 倍（95%CI，1.43-1.69），而高血压的几率降低了（0.94 [95%CI，0.92-0.97]）。
ABO 血型系统与健康衰老和疾病发展的几个参数相关。ABO 血型知识可能对更个性化的健康维护和疾病预防方法感兴趣。
