Länsitie Miia, Kangas Maarit, Jokelainen Jari, Venojärvi Mika, Vaaramo Eeva, Härkönen Pirjo, Keinänen-Kiukaanniemi Sirkka, Korpelainen Raija
Department of Sports and Exercise Medicine, Oulu Deaconess Institute Foundation sr., Oulu, Finland; Center for Life Course Health Research, University of Oulu, Oulu, Finland; Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland.
Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland.
Diabetes Res Clin Pract. 2021 Aug;178:108937. doi: 10.1016/j.diabres.2021.108937. Epub 2021 Jul 1.
To examine the association of physical activity (PA) and sedentary time (ST) with glucose metabolism according to waist circumference (WC) in older people.
A population-based sample of 702 individuals (aged 67-70 years) wore wrist-worn accelerometers for two weeks and underwent an oral glucose tolerance test. The associations between moderate-to-vigorous (MVPA) and light (LPA) PA, ST, and glucose metabolism across the tertiles of WC were analysed using general linear regression.
Among highest WC tertile, LPA negatively associated with fasting insulin (β = - 0.047, 95% CI - 0.082 to - 0.012), HOMA-IR (β = - 0.098, 95% CI - 0.184 to - 0.012), and HOMA-β (β = - 3.367, CI - 6.570 to - 0.783). ST associated with 120 min glucose (β = 0.140, CI 0.021 to 0.260). Among lowest WC tertile, MVPA negatively associated with 30 min insulin (β = - 0.086, 95% CI - 0.168 to - 0.004) and 120 min insulin (β = - 0.160, 95% CI - 0.257 to - 0.063) and positively associated with Matsuda index (β = 0.076, 95% CI 0.014 to 0.139). Light PA negatively associated with 120 min insulin (β = - 0.054, 95% CI - 0.104 to - 0.005).
With the limitation of the cross-sectional study, reducing ST and increasing LPA may be beneficial for glucose metabolism among abdominally obese older adults. Lean older adults could benefit more from increasing MVPA.
根据老年人的腰围（WC），研究身体活动（PA）和久坐时间（ST）与葡萄糖代谢之间的关联。
一项基于人群的样本研究，纳入了702名年龄在67 - 70岁之间的个体，他们佩戴腕式加速度计两周，并接受口服葡萄糖耐量试验。使用一般线性回归分析了中等至剧烈（MVPA）和轻度（LPA）PA、ST以及WC三分位数之间的葡萄糖代谢关联。
在WC最高三分位数组中，LPA与空腹胰岛素（β = -0.047，95%CI -0.082至-0.012）、HOMA-IR（β = -0.098，95%CI -0.184至-0.012）和HOMA-β（β = -3.367，CI -6.570至-0.783）呈负相关。ST与120分钟血糖（β = 0.140，CI 0.021至0.260）相关。在WC最低三分位数组中，MVPA与30分钟胰岛素（β = -0.086，95%CI -0.168至-0.004）和120分钟胰岛素（β = -0.160，95%CI -0.257至-0.063）呈负相关，与松田指数（β = 0.076，95%CI 从0.014至0.139）呈正相关。轻度PA与120分钟胰岛素（β = -0.054，95%CI -0.104至-0.005）呈负相关。
受横断面研究的局限性，减少ST和增加LPA可能对腹部肥胖老年人的葡萄糖代谢有益。体型瘦的老年人可能从增加MVPA中获益更多。
