客观测量的身体活动和久坐时间与糖尿病前期成年人的心血管代谢危险因素相关：PREVIEW 研究。

Objectively Measured Physical Activity and Sedentary Time Are Associated With Cardiometabolic Risk Factors in Adults With Prediabetes: The PREVIEW Study.

机构信息

Swansea University, Swansea, Wales, U.K.

Division of Human Nutrition, Wageningen University & Research, Wageningen, the Netherlands.

出版信息

Diabetes Care. 2018 Mar;41(3):562-569. doi: 10.2337/dc17-1057. Epub 2017 Nov 20.

DOI:10.2337/dc17-1057

PMID:29158249

Abstract

OBJECTIVE

The aim of the present cross-sectional study was to examine the association among physical activity (PA), sedentary time (ST), and cardiometabolic risk in adults with prediabetes.

RESEARCH DESIGN AND METHODS

Participants ( = 2,326; 25-70 years old, 67% female) from eight countries, with a BMI >25 kg ⋅ m and impaired fasting glucose (5.6-6.9 mmol ⋅ L) or impaired glucose tolerance (7.8-11.0 mmol ⋅ L at 2 h), participated. Seven-day accelerometry objectively assessed PA levels and ST.

RESULTS

Multiple linear regression revealed that moderate-to-vigorous PA (MVPA) was negatively associated with HOMA of insulin resistance (HOMA-IR) (standardized β = -0.078 [95% CI -0.128, -0.027]), waist circumference (WC) (β = -0.177 [-0.122, -0.134]), fasting insulin (β = -0.115 [-0.158, -0.072]), 2-h glucose (β = -0.069 [-0.112, -0.025]), triglycerides (β = -0.091 [-0.138, -0.044]), and CRP (β = -0.086 [-0.127, -0.045]). ST was positively associated with HOMA-IR (β = 0.175 [0.114, 0.236]), WC (β = 0.215 [0.026, 0.131]), fasting insulin (β = 0.155 [0.092, 0.219]), triglycerides (β = 0.106 [0.052, 0.16]), CRP (β = 0.106 [0.39, 0.172]), systolic blood pressure (BP) (β = 0.078 [0.026, 0.131]), and diastolic BP (β = 0.106 [0.39, -0.172]). Associations reported between total PA (counts ⋅ min), and all risk factors were comparable or stronger than for MVPA: HOMA-IR (β = -0.151 [-0.194, -0.107]), WC (β = -0.179 [-0.224, -0.134]), fasting insulin (β = -0.139 [-0.183, -0.096]), 2-h glucose (β = -0.088 [-0.131, -0.045]), triglycerides (β = -0.117 [-0.162, -0.071]), and CRP (β = -0.104 [-0.146, -0.062]).

CONCLUSIONS

In adults with prediabetes, objectively measured PA and ST were associated with cardiometabolic risk markers. Total PA was at least as strongly associated with cardiometabolic risk markers as MVPA, which may imply that the accumulation of total PA over the day is as important as achieving the intensity of MVPA.

摘要

目的

本横断面研究的目的是检验体力活动（PA）、久坐时间（ST）与糖尿病前期成年人代谢风险之间的关联。

研究设计和方法

来自八个国家的参与者（n=2326；年龄 25-70 岁，67%为女性，BMI＞25kg ⋅ m，空腹血糖受损（5.6-6.9mmol ⋅ L）或糖耐量受损（2h 时 7.8-11.0mmol ⋅ L））参与了研究。7 天加速计客观评估 PA 水平和 ST。

结果

多线性回归显示，中高强度 PA（MVPA）与胰岛素抵抗的 HOMA（HOMA-IR）（标准化β=-0.078[95%CI-0.128，-0.027]）、腰围（WC）（β=-0.177[-0.122，-0.134]）、空腹胰岛素（β=-0.115[-0.158，-0.072]）、2h 血糖（β=-0.069[-0.112，-0.025]）、甘油三酯（β=-0.091[-0.138，-0.044]）和 CRP（β=-0.086[-0.127，-0.045]）呈负相关。ST 与 HOMA-IR（β=0.175[0.114，0.236]）、WC（β=0.215[0.026，0.131]）、空腹胰岛素（β=0.155[0.092，0.219]）、甘油三酯（β=0.106[0.052，0.16]）、CRP（β=0.106[0.39，0.172]）、收缩压（BP）（β=0.078[0.026，0.131]）和舒张压（β=0.106[0.39，-0.172]）呈正相关。总 PA（计数 ⋅ 分钟）与所有风险因素的相关性报告与 MVPA 相当或更强：HOMA-IR（β=-0.151[-0.194，-0.107]）、WC（β=-0.179[-0.224，-0.134]）、空腹胰岛素（β=-0.139[-0.183，-0.096]）、2h 血糖（β=-0.088[-0.131，-0.045]）、甘油三酯（β=-0.117[-0.162，-0.071]）和 CRP（β=-0.104[-0.146，-0.062]）。