Swansea University, Swansea, Wales, U.K.
Division of Human Nutrition, Wageningen University & Research, Wageningen, the Netherlands.
Diabetes Care. 2018 Mar;41(3):562-569. doi: 10.2337/dc17-1057. Epub 2017 Nov 20.
The aim of the present cross-sectional study was to examine the association among physical activity (PA), sedentary time (ST), and cardiometabolic risk in adults with prediabetes.
Participants ( = 2,326; 25-70 years old, 67% female) from eight countries, with a BMI >25 kg ⋅ m and impaired fasting glucose (5.6-6.9 mmol ⋅ L) or impaired glucose tolerance (7.8-11.0 mmol ⋅ L at 2 h), participated. Seven-day accelerometry objectively assessed PA levels and ST.
Multiple linear regression revealed that moderate-to-vigorous PA (MVPA) was negatively associated with HOMA of insulin resistance (HOMA-IR) (standardized β = -0.078 [95% CI -0.128, -0.027]), waist circumference (WC) (β = -0.177 [-0.122, -0.134]), fasting insulin (β = -0.115 [-0.158, -0.072]), 2-h glucose (β = -0.069 [-0.112, -0.025]), triglycerides (β = -0.091 [-0.138, -0.044]), and CRP (β = -0.086 [-0.127, -0.045]). ST was positively associated with HOMA-IR (β = 0.175 [0.114, 0.236]), WC (β = 0.215 [0.026, 0.131]), fasting insulin (β = 0.155 [0.092, 0.219]), triglycerides (β = 0.106 [0.052, 0.16]), CRP (β = 0.106 [0.39, 0.172]), systolic blood pressure (BP) (β = 0.078 [0.026, 0.131]), and diastolic BP (β = 0.106 [0.39, -0.172]). Associations reported between total PA (counts ⋅ min), and all risk factors were comparable or stronger than for MVPA: HOMA-IR (β = -0.151 [-0.194, -0.107]), WC (β = -0.179 [-0.224, -0.134]), fasting insulin (β = -0.139 [-0.183, -0.096]), 2-h glucose (β = -0.088 [-0.131, -0.045]), triglycerides (β = -0.117 [-0.162, -0.071]), and CRP (β = -0.104 [-0.146, -0.062]).
In adults with prediabetes, objectively measured PA and ST were associated with cardiometabolic risk markers. Total PA was at least as strongly associated with cardiometabolic risk markers as MVPA, which may imply that the accumulation of total PA over the day is as important as achieving the intensity of MVPA.
本横断面研究的目的是检验体力活动（PA）、久坐时间（ST）与糖尿病前期成年人代谢风险之间的关联。
来自八个国家的参与者（n=2326；年龄 25-70 岁，67%为女性，BMI＞25kg ⋅ m，空腹血糖受损（5.6-6.9mmol ⋅ L）或糖耐量受损（2h 时 7.8-11.0mmol ⋅ L））参与了研究。7 天加速计客观评估 PA 水平和 ST。
多线性回归显示，中高强度 PA（MVPA）与胰岛素抵抗的 HOMA（HOMA-IR）（标准化β=-0.078[95%CI-0.128，-0.027]）、腰围（WC）（β=-0.177[-0.122，-0.134]）、空腹胰岛素（β=-0.115[-0.158，-0.072]）、2h 血糖（β=-0.069[-0.112，-0.025]）、甘油三酯（β=-0.091[-0.138，-0.044]）和 CRP（β=-0.086[-0.127，-0.045]）呈负相关。ST 与 HOMA-IR（β=0.175[0.114，0.236]）、WC（β=0.215[0.026，0.131]）、空腹胰岛素（β=0.155[0.092，0.219]）、甘油三酯（β=0.106[0.052，0.16]）、CRP（β=0.106[0.39，0.172]）、收缩压（BP）（β=0.078[0.026，0.131]）和舒张压（β=0.106[0.39，-0.172]）呈正相关。总 PA（计数 ⋅ 分钟）与所有风险因素的相关性报告与 MVPA 相当或更强：HOMA-IR（β=-0.151[-0.194，-0.107]）、WC（β=-0.179[-0.224，-0.134]）、空腹胰岛素（β=-0.139[-0.183，-0.096]）、2h 血糖（β=-0.088[-0.131，-0.045]）、甘油三酯（β=-0.117[-0.162，-0.071]）和 CRP（β=-0.104[-0.146，-0.062]）。
在糖尿病前期成年人中，体力活动和久坐时间与代谢风险标志物相关。总 PA 与代谢风险标志物的相关性至少与 MVPA 一样强，这可能意味着一天中总 PA 的积累与达到 MVPA 的强度一样重要。
