Department of Orthopaedics, West China Hospital, Sichuan University, No. 37 Guoxue Lane, 610041 Chengdu, Sichuan, People's Republic of China.
Department of Gastroenterology, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, No. 46 Chongxin Road, 541002 Guilin City, Guangxi Zhuang Autonomous Region, People's Republic of China.
Orthop Traumatol Surg Res. 2021 Oct;107(6):103007. doi: 10.1016/j.otsr.2021.103007. Epub 2021 Jul 1.
Recently, local platelet-rich plasma (PRP) injection has been gradually used in the treatment of plantar fasciitis (PF). However, compared with traditional steroid injection, the clinical results of local PRP injection for PF patients remain controversial. Therefore, we performed a systematic review to focus on two questions as follows: (1) is PRP more effective than steroid to relieve pain in PF patients? (2) is PRP more effective than steroid to improve the foot and ankle function of PF patients?
The PRP could be more effective to relieve pain and improve the foot and ankle function in PF patients.
We systematically searched electronic databases (Cochrane Central Register of Controlled Trials, MEDLINE, PubMed, Web of Science, and Embase) from inception to October 20, 2019. The data of clinical results, including visual analogue scale (VAS) and American Orthopedic Foot and Ankle Society (AOFAS) scores, were extracted and analyzed.
Finally, twelve randomized controlled trials (RCT), involving 653 PF patients, were enrolled. All enrolled trials were considered to be of high quality. The results showed that the VAS of the PRP group was significantly lower than that of the steroid group at 6-month (p=0.02), 1-year (p=0.02), and 1.5-year (p<0.00001) follow-up. The AOFAS scores of the PRP group were significantly higher than that of the steroid group at 1-year (p=0.005) follow-up.
Compared to local steroid injection, local autologous PRP injection is more effective in relieving pain and improving the foot and ankle function at mid-term follow-up.
II; Systematic review and Meta-analysis.
最近，局部富血小板血浆（PRP）注射已逐渐用于足底筋膜炎（PF）的治疗。然而，与传统的类固醇注射相比，局部 PRP 注射治疗 PF 患者的临床效果仍存在争议。因此，我们进行了一项系统评价，重点关注以下两个问题：（1）PRP 缓解 PF 患者疼痛是否比类固醇更有效？（2）PRP 改善 PF 患者足踝功能是否比类固醇更有效？
PRP 可能更有效地缓解 PF 患者的疼痛并改善其足踝功能。
我们系统地检索了电子数据库（Cochrane 对照试验中心注册库、MEDLINE、PubMed、Web of Science 和 Embase），检索时间从建库至 2019 年 10 月 20 日。提取并分析了临床结果（包括视觉模拟评分（VAS）和美国矫形足踝协会（AOFAS）评分）的数据。
最终纳入了 12 项随机对照试验（RCT），共纳入 653 例 PF 患者。所有纳入的试验均被认为是高质量的。结果表明，在 6 个月（p=0.02）、1 年（p=0.02）和 1.5 年（p<0.00001）随访时，PRP 组的 VAS 显著低于类固醇组。在 1 年随访时（p=0.005），PRP 组的 AOFAS 评分显著高于类固醇组。
与局部类固醇注射相比，局部自体 PRP 注射在中期随访时更能有效缓解疼痛和改善足踝功能。
II；系统评价和 Meta 分析。
