McConchie J M, Richardson A S, Hole L W, McCombie F
Community Dent Oral Epidemiol. 1977 Nov;5(6):278-83. doi: 10.1111/j.1600-0528.1977.tb01014.x.
The effectiveness of a stannous fluoride mouthrinse, when used once each school day, was investigated in a 3-year study. Effervescent stannous fluoride tablets of two concentrations were dissolved in 20 ml of water, giving solutions of 100 parts/10(6)F- and 200 parts/10(6)F- respectively. Approximately 1,200 children, with a mean age of 10 years, were divided on a random basis into three groups. Two of the groups rinsed with the two strengths of solution and the third group rinsed with a placebo. Examinations were carried out at the commencement of the study, and at yearly intervals thereafter. The final series was carried out a year after the rinsing procedures were terminated. There were significant reductions in the numbers of new caries in each of the two experimental groups as compared with the controls. The concentration of the solutions appeared to have little influence on the results. More dramatic reductions were noted in the teeth which erupted during the course of the study. A residual effect was demonstrated a year after the rinsing procedures were terminated.
一项为期3年的研究对每天在学校使用一次的氟化亚锡漱口水的效果进行了调查。将两种浓度的泡腾氟化亚锡片溶解在20毫升水中，分别得到100 ppm F⁻和200 ppm F⁻的溶液。约1200名平均年龄为10岁的儿童被随机分为三组。其中两组用两种不同浓度的溶液漱口，第三组用安慰剂漱口。在研究开始时以及此后每年进行检查。最后一组检查在漱口程序结束一年后进行。与对照组相比，两个实验组的新发龋数均有显著减少。溶液浓度似乎对结果影响不大。在研究过程中萌出的牙齿龋数减少更为显著。漱口程序结束一年后仍显示有残留效应。
