Hendriks Paul M, van Thor Mitch C J, Wapenaar Monique, Chandoesing Prewesh, van den Toorn Leon M, van den Bosch Annemien E, Post Marco C, Boomars Karin A
Department of Respiratory Medicine, Erasmus MC, University Medical Centre Rotterdam, Doctor Molewaterplein 40, 3015 GD Rotterdam, the Netherlands; Department of Cardiology, Erasmus MC, University Medical Centre Rotterdam, Doctor Molewaterplein 40, 3015 GD Rotterdam, the Netherlands.
Department of Cardiology, St. Antonius Hospital, Koekoekslaan 1, 3435CM Nieuwegein, the Netherlands.
Respir Med. 2021 Sep;186:106525. doi: 10.1016/j.rmed.2021.106525. Epub 2021 Jun 29.
Health-related quality of life (HRQoL) is impaired in patients with pulmonary hypertension (PH). The EmPHasis-10 and CAMPHOR questionnaires are developed to evaluate HRQoL specifically in patients with PH. Data on the longitudinal use of both questionnaires are still limited. We evaluated the longitudinal value of both questionnaires and established minimal clinically important differences (MCID).
Sixty-one treatment naïve pulmonary arterial hypertension or chronic thromboembolic patients were prospectively included. Patients were treated according to the current ESC/ERS guidelines. We compared EmPHasis-10 and CAMPHOR scores between baseline, 6 and 12 months of follow-up and evaluated the correlation between these scores and a 5-scale symptom severity score, 5-scale overall health score, NYHA-classification, 6 min walk test distance (6MWD), NT-proBNP and echocardiographic parameters.
After one year of treatment a significant reduction in EmPHasis-10 score and CAMPHOR QoL and symptoms domain score was observed. Moderate to good correlations were observed between the questionnaires and the overall-health and symptom severity score and 6MWD. No relevant correlations were seen between the questionnaires and NT-pro-BNP and echocardiographic parameters. EmPHasis-10 scores showed strong correlations with all CAMPHOR domains. The MCID for the EmPHasis-10 questionnaire was -8. The MCIDs for the CAMPHOR domains were: activity -3, symptoms -4, QoL -3.
The EmPHasis-10 and CAMPHOR questionnaires are valid tools for the longitudinal measurement of HRQoL in patients with PH. The much shorter EmPHasis-10 correlates well with the CAMPHOR domain scores and with the clinical endpoints and it may be easier to use in daily practice.
肺动脉高压（PH）患者的健康相关生活质量（HRQoL）受损。EmPHasis - 10和CAMPHOR问卷专门用于评估PH患者的HRQoL。关于这两种问卷纵向使用的数据仍然有限。我们评估了这两种问卷的纵向价值并确定了最小临床重要差异（MCID）。
前瞻性纳入61例初治的肺动脉高压或慢性血栓栓塞患者。患者按照当前的ESC/ERS指南进行治疗。我们比较了基线、随访6个月和12个月时的EmPHasis - 10和CAMPHOR评分，并评估了这些评分与5级症状严重程度评分、5级总体健康评分、纽约心脏协会（NYHA）分级、6分钟步行试验距离（6MWD）、N末端脑钠肽前体（NT - proBNP）和超声心动图参数之间的相关性。
治疗一年后，观察到EmPHasis - 10评分、CAMPHOR生活质量和症状领域评分显著降低。问卷与总体健康和症状严重程度评分以及6MWD之间观察到中度至良好的相关性。问卷与NT - pro - BNP和超声心动图参数之间未发现相关相关性。EmPHasis - 10评分与所有CAMPHOR领域均显示出强相关性。EmPHasis - 10问卷的MCID为 - 8。CAMPHOR各领域的MCID分别为：活动 - 3、症状 - 4、生活质量 - 3。
EmPHasis - 10和CAMPHOR问卷是纵向测量PH患者HRQoL的有效工具。更简短的EmPHasis - 10与CAMPHOR领域评分以及临床终点相关性良好，并且在日常实践中可能更易于使用。
