Metwalley Kotb Abbass, Farghaly Hekma Saad
Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt.
Ann Pediatr Endocrinol Metab. 2021 Jun;26(2):80-85. doi: 10.6065/apem.2040242.121. Epub 2021 Jun 30.
Subclinical hypothyroidism (SH) is defined as serum thyroid-stimulating hormone (TSH) above the upper limit of the reference range in the presence of normal free T4 concentrations. Depending on the degree of TSH elevation, SH could be defined as mild (TSH, 4.5-10 mIU/L) or severe (TSH>10 mIU/L). While there is a general consensus to treat children with serum TSH levels above 10 mU/L, the management of the mild form is uncertain and should be individualized. In this mini-review, we present a brief review of SH in children based on extensive literature review and long-standing clinical experience. This review provides the prevalence, causes, clinical presentation, consequences, investigation, and up-to-date therapeutic approach of SH in children. Generally, the purpose of the review is to provide pediatricians with an update of this common and continuously evolving condition.
亚临床甲状腺功能减退症（SH）的定义为，在游离T4浓度正常的情况下，血清促甲状腺激素（TSH）高于参考范围的上限。根据TSH升高的程度，SH可分为轻度（TSH，4.5 - 10 mIU/L）或重度（TSH>10 mIU/L）。虽然对于血清TSH水平高于10 mU/L的儿童进行治疗已达成普遍共识，但轻度形式的管理尚不确定，应个体化。在本综述中，我们基于广泛的文献综述和长期的临床经验，对儿童SH进行简要回顾。本综述提供了儿童SH的患病率、病因、临床表现、后果、检查及最新治疗方法。总体而言，本综述的目的是为儿科医生提供有关这种常见且不断演变的病症的最新信息。
