Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.
Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, China.
J Obstet Gynaecol Res. 2021 Sep;47(9):3379-3384. doi: 10.1111/jog.14892. Epub 2021 Jul 4.
A 31-year-old woman, who had been diagnosed with craniopharyngioma (CP) at the age of 13, suffered secondary hypopituitarism after two surgical resections of CP, receiving supplement of levothyroxine, cortisone, and sequential estrogen and progesterone because of primary amenorrhea. She managed to conceive after ovulation induction with human menopausal gonadotropin. Luteal phase deficiency (LPD) was found during the first trimester, as the progesterone stayed at a low level between 0.07 and 1.63 ng/ml within seven gestational weeks, followed by a gradual rise from 4.01 up to 34.70 ng/ml in the 11th week, which was mainly secreted by the placenta. Estrogen and progesterone were administered to the patient as luteal support until the 12th week, who succeeded in delivering a healthy baby at term. In conclusion, the patient with hypopituitarism who develops severe LPD during the early pregnancy may need luteal support until 12th week.
一位 31 岁的女性，13 岁时被诊断为颅咽管瘤（CP），在两次 CP 手术后患有继发性垂体功能减退症，由于原发性闭经，她接受了左甲状腺素、皮质醇、序贯雌激素和孕激素的补充治疗。她成功地在促排卵后怀孕。在孕早期发现黄体期缺陷（LPD），因为在妊娠 7 周内孕激素水平一直保持在低水平，在 0.07 至 1.63ng/ml 之间，随后在第 11 周逐渐上升至 4.01 至 34.70ng/ml，这主要由胎盘分泌。患者接受了雌激素和孕激素的黄体支持治疗，直到第 12 周，成功地足月分娩了一个健康的婴儿。总之，患有垂体功能减退症的患者在孕早期发生严重的 LPD 时，可能需要黄体支持治疗至第 12 周。
