在英国生物库中检测 APOE 和 Klotho 基因型对认知、痴呆和脑成像指标的交互作用。
Testing for Interactions Between APOE and Klotho Genotypes on Cognitive, Dementia, and Brain Imaging Metrics in UK Biobank.
机构信息
Institute of Health & Wellbeing, University of Glasgow, Glasgow, Scotland, UK.
Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, Scotland, UK.
出版信息
J Alzheimers Dis. 2021;83(1):51-55. doi: 10.3233/JAD-210181.
Recent research suggests genetic variation in the Klotho locus may modify the association between APOE ɛ4 and cognitive impairment. We tested for associations and interactions between these genotypes versus risk of dementia, cognitive abilities, and brain structure in older UK Biobank participants. Klotho status was indexed with rs9536314 heterozygosity (versus not), in unrelated people with versus without APOE ɛ4 genotype, corrected for various confounders. APOE ɛ4 associated with increased risk of dementia, worse cognitive abilities, and brain structure. Klotho was associated with better reasoning. There were no interactions; potentially suggesting an age- and pathology-dependent Klotho effect.
最近的研究表明，Klotho 基因座的遗传变异可能会改变 APOE ɛ4 与认知障碍之间的关联。我们在英国生物银行的老年参与者中测试了这些基因型与痴呆风险、认知能力和大脑结构之间的关联和相互作用。Klotho 状态通过 rs9536314 杂合性（与非杂合性相比）来表示，APOE ɛ4 基因型的有无，经过各种混杂因素的校正。APOE ɛ4 与痴呆风险增加、认知能力下降和大脑结构有关。Klotho 与更好的推理能力有关。没有相互作用，这可能表明 Klotho 效应与年龄和病理有关。
Zotero 插件