1University Hospital of Split, Nuclear medicine department, Split, Croatia; 2University Hospital of Split, ENT department, Split, Croatia; 3University Hospital of Split, Radiology department, Split, Croatia; 4University Hospital of Split, Department for pathology, Split, Croatia.
Acta Clin Croat. 2020 Jun;59(Suppl 1):146-148. doi: 10.20471/acc.2020.59.s1.19.
Diffuse toxic goiter, as the most common cause of hyperthyroidism, is usually initially treated with thyrostatic drugs such as methimazole, followed by radioiodine therapy or surgery which may be indicated as definitive treatment. Radioactive iodine therapy has a known association with various histopathologic features including cytologic atypia, but herein we present a rare example of morphological thyrocyte changes induced by long-term pharmacological treatment with methimazole that mimicked thyroid malignancy in a pathohistological sample.
弥漫性毒性甲状腺肿是引起甲状腺功能亢进症最常见的原因，通常最初采用甲巯咪唑等甲状腺抑制剂进行治疗，随后可采用放射性碘治疗或手术治疗，后者可能作为确定性治疗方法。放射性碘治疗与各种组织病理学特征有关，包括细胞学异型性，但本文报道了一个罕见的长期甲巯咪唑药物治疗引起的形态学甲状腺细胞变化的病例，该病例在病理组织学样本中类似于甲状腺恶性肿瘤。
