Ahmed Moeed, Jagadesh Sunil K, Alhajhusain Mohamad Ali, Mutnuri Sangeeta
Creighton University School of Medicine, Omaha, Nebraska.
Proc (Bayl Univ Med Cent). 2021 Apr 9;34(4):521-522. doi: 10.1080/08998280.2021.1906828.
Propylene glycol is a viscous, colorless liquid that has been approved by the US Food and Drug Administration for use as a preservative in foods and as a solvent in pharmaceuticals. Compared with methanol and ethylene glycol, it is regarded as a relatively safe alcohol. There have been several reports of severe lactic acidosis in the setting of iatrogenic unintentional overdosing of medications that use propylene glycol as a diluent, including lorazepam and diazepam. The laboratory findings may include high metabolic acidosis and high osmolal gap. Propylene glycol is also one of the ingredients used in Fireball Whiskey. We present two cases of severe lactic acidosis in the setting of Fireball Whiskey use.
丙二醇是一种粘稠的无色液体，已获美国食品药品监督管理局批准，可作为食品防腐剂和药品溶剂使用。与甲醇和乙二醇相比，它被认为是一种相对安全的醇类。有几份报告称，在医源性无意过量使用以丙二醇为稀释剂的药物（包括劳拉西泮和地西泮）的情况下，会出现严重乳酸酸中毒。实验室检查结果可能包括高代谢性酸中毒和高渗透压间隙。丙二醇也是火球威士忌（Fireball Whiskey）的成分之一。我们报告两例在饮用火球威士忌后出现严重乳酸酸中毒的病例。
