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[用铁卟啉寡核苷酸衍生物对单链DNA片段进行互补寻址修饰]

[Complementary-addressed modification of a single-stranded DNA fragment with an iron-porphyrin oligonucleotide derivative].

作者信息

Ivanova E M, Mamaev S V, Fedorova O S, Frolova E I

出版信息

Bioorg Khim. 1988 Apr;14(4):551-4.

PMID:3422008
Abstract

Hemin was attached covalently to the 5'-terminus of the 14-mer d(pTGACCCTCTT.CCC)rA and was shown, in the presence of oxygen and a reducing agent, to be active in the cleavage of the complementary sequence (position 261-274) in a 303 nucleotide-long DNA fragment. The yield of the cleavage products reached approximately 50%, the cleavage locus comprising two bases (G275 and G276).

摘要

血红素共价连接到14聚体d(pTGACCCTCTT.CCC)rA的5'-末端，并且在氧气和还原剂存在的情况下，它在切割一个303个核苷酸长的DNA片段中的互补序列（位置261 - 274）时具有活性。切割产物的产率达到约50%，切割位点包含两个碱基（G275和G276）。

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