静脉注射脉冲环磷酰胺和甲泼尼龙逆转进行性坏死性血管炎。
Reversal of progressive necrotizing vasculitis with intravenous pulse cyclophosphamide and methylprednisolone.
作者信息
Fort J G, Abruzzo J L
机构信息
Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.
出版信息
Arthritis Rheum. 1988 Sep;31(9):1194-8. doi: 10.1002/art.1780310918.
PMID:3422017
Abstract
We describe a patient with polyarteritis nodosa who, despite therapy with daily doses of oral prednisone and cyclophosphamide, developed acute renal failure. Renal histopathologic examination demonstrated crescentic glomerulonephritis. Treatment with intravenous pulse cyclophosphamide and methylprednisolone resulted in clinical improvement and significant recovery of renal function.
摘要
我们描述了一名结节性多动脉炎患者，尽管每日口服泼尼松和环磷酰胺进行治疗，但仍发展为急性肾衰竭。肾脏组织病理学检查显示为新月体性肾小球肾炎。静脉注射脉冲环磷酰胺和甲基泼尼松龙治疗后，临床症状改善，肾功能显著恢复。
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