• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

自然周期中人类子宫内膜液的抗菌和抗真菌活性。

Antibacterial and Antifungal Activity of the Human Endometrial Fluid during the Natural Cycle.

机构信息

Department of Nursing, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, Barrio Sarriena s/n, 48940-Leioa, Spain.

Proteomics Platform, CIC bioGUNE, CIBERehd, ProteoRed-ISCIII, Bizkaia Science and Technology Park, Derio, Spain.

出版信息

Infect Dis Obstet Gynecol. 2021 Jun 16;2021:8849664. doi: 10.1155/2021/8849664. eCollection 2021.

DOI:10.1155/2021/8849664
PMID:34220191
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8221874/
Abstract

PURPOSE

Some microbiota patterns have been associated with favorable IVF prognosis and others with pathological conditions. The endometrial fluid aspirate (EFA) contains antibacterial proteins that are enriched in implantative IVF cycles, but the antimicrobial effect of EFA has not been addressed. We aimed to evaluate the antimicrobial activity of the human endometrial fluid during the natural cycle.

METHODS

EFA was obtained through an embryo transfer catheter in 38 women, aged 18-40 years, with regular cycles attending to a fertility clinic. The antimicrobial activity of EFAs was tested against two strains of ; one strain each of , , , and ; and three yeasts (, , and ).

RESULTS

All samples exhibited antibacterial activity against . In addition, 32.4% of EFAs were active against one of the other microorganisms assayed, 16.2% against two, and 5.4% against four of them. In contrast, none exhibited antibacterial activity against or . The antimicrobial activity differs considerably between EFA samples, and we failed to observe a cycle-related pattern.

CONCLUSIONS

EFA presented two antimicrobial activity patterns: (a) one common to all the samples, exhibiting activity against and lack of activity against and , and (b) an individualized pattern, showing activity against some of the other microorganisms tested. The intensity of antibacterial activity differs between EFA samples. Our data suggest that the uterine microbiota is controlled by means of endometrial fluid components.

摘要

目的

一些微生物群模式与体外受精（IVF）的良好预后相关，而另一些与病理状况相关。子宫内膜液抽吸物（EFA）含有在植入性 IVF 周期中丰富的抗菌蛋白，但 EFA 的抗菌作用尚未得到解决。我们旨在评估自然周期中人类子宫内膜液的抗菌活性。

方法

38 名年龄在 18-40 岁之间、有规律周期的女性在生殖诊所就诊时，通过胚胎转移导管获得 EFA。测试了 EFAs 对两种 的抗菌活性；每种 各一种、 、 、 和三种酵母（ 、 和 ）。

结果

所有样本均对 表现出抗菌活性。此外，32.4%的 EFAs 对其他三种微生物中的一种有活性，16.2%对两种有活性，5.4%对四种有活性。相比之下，没有一种对 或 表现出抗菌活性。EFA 的抗菌活性差异很大，我们未能观察到与周期相关的模式。

结论

EFA 呈现出两种抗菌活性模式：（a）所有样本共有的模式，对 表现出活性，对 和 缺乏活性，（b）个体模式，对其他一些测试的微生物表现出活性。EFA 之间的抗菌活性强度不同。我们的数据表明，子宫微生物群受子宫内膜液成分的控制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91f6/8221874/0e0461ce0a9d/IDOG2021-8849664.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91f6/8221874/0e0461ce0a9d/IDOG2021-8849664.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91f6/8221874/0e0461ce0a9d/IDOG2021-8849664.001.jpg

相似文献

1
Antibacterial and Antifungal Activity of the Human Endometrial Fluid during the Natural Cycle.自然周期中人类子宫内膜液的抗菌和抗真菌活性。
Infect Dis Obstet Gynecol. 2021 Jun 16;2021:8849664. doi: 10.1155/2021/8849664. eCollection 2021.
2
Differential proteomic analysis of endometrial fluid suggests increased inflammation and impaired glucose metabolism in non-implantative IVF cycles and pinpoints PYGB as a putative implantation marker.子宫内膜液的差异蛋白质组学分析表明，非着床性 IVF 周期中炎症增加和葡萄糖代谢受损，并指出 PYGB 是一个潜在的着床标志物。
Hum Reprod. 2018 Oct 1;33(10):1898-1906. doi: 10.1093/humrep/dey274.
3
Antimicrobial activities of some tetrahydronaphthalene-benzimidazole derivatives.某些四氢萘-苯并咪唑衍生物的抗菌活性。
Chemotherapy. 2007;53(2):110-3. doi: 10.1159/000100011. Epub 2007 Feb 19.
4
Synthesis and antimicrobial properties of naphthylamine derivatives having a thiazolidinone moiety.具有噻唑烷酮部分的萘胺衍生物的合成及抗菌性能。
Medicina (Kaunas). 2011;47(6):334-9.
5
Catechol-bearing imidazolium and benzimidazolium chlorides as promising antimicrobial agents.含儿茶酚的咪唑𬭩和苯并咪唑𬭩氯化物作为有前途的抗菌剂。
Arch Pharm (Weinheim). 2020 Jun;353(6):e2000013. doi: 10.1002/ardp.202000013. Epub 2020 Apr 17.
6
Antimicrobial activity of novel 5-benzylidene-3-(3-phenylallylideneamino)imidazolidine-2,4-dione derivatives causing clinical pathogens: Synthesis and molecular docking studies.新型 5-亚苄基-3-(3-苯丙烯亚胺基)咪唑烷-2,4-二酮衍生物对临床病原体的抗菌活性：合成与分子对接研究。
J Infect Public Health. 2020 Dec;13(12):1951-1960. doi: 10.1016/j.jiph.2020.09.017. Epub 2020 Oct 21.
7
Novel benzoxazoles: synthesis and antibacterial, antifungal, and antitubercular activity against antibiotic-resistant and -sensitive microbes.新型苯并恶唑类化合物的合成及其对耐抗生素和敏感微生物的抗菌、抗真菌和抗结核活性。
Z Naturforsch C J Biosci. 2013 Nov-Dec;68(11-12):453-60.
8
Antimicrobial, modulatory and chemical analysis of the oil of Croton limae.巴豆属利马种油的抗菌、调节及化学分析
Pharm Biol. 2017 Dec;55(1):2015-2019. doi: 10.1080/13880209.2017.1355926.
9
Synthesis and antimicrobial activity of some novel phenyl and benzimidazole substituted benzyl ethers.一些新型苯基和苯并咪唑取代苄基醚的合成及其抗菌活性
Bioorg Med Chem Lett. 2007 Apr 15;17(8):2233-6. doi: 10.1016/j.bmcl.2007.01.061. Epub 2007 Jan 25.
10
[Comparative studies on activities of antimicrobial agents against causative organisms isolated from patients with urinary tract infections (1996). I. Susceptibility distribution].[1996年抗微生物药物对尿路感染患者分离出的病原体的活性比较研究。I. 敏感性分布]
Jpn J Antibiot. 1998 Feb;51(2):69-111.

引用本文的文献

1
Natural killer cell subsets in endometrial fluid: a pilot study of their association with the endometrial cycle and reproductive parameters.子宫内膜液中的自然杀伤细胞亚群：与子宫内膜周期和生殖参数关联的初步研究。
J Assist Reprod Genet. 2023 Sep;40(9):2241-2250. doi: 10.1007/s10815-023-02862-4. Epub 2023 Jul 12.

本文引用的文献

1
In-depth proteomics and natural peptidomics analyses reveal antibacterial peptides in human endometrial fluid.深入的蛋白质组学和天然肽组学分析揭示了人子宫内膜液中的抗菌肽。
J Proteomics. 2020 Mar 30;216:103652. doi: 10.1016/j.jprot.2020.103652. Epub 2020 Jan 18.
2
Characterization of Microbiota in Endometrial Fluid and Vaginal Secretions in Infertile Women with Repeated Implantation Failure.反复着床失败不孕患者的子宫内膜液和阴道分泌物中的微生物组特征。
Mediators Inflamm. 2019 May 21;2019:4893437. doi: 10.1155/2019/4893437. eCollection 2019.
3
A pilot study and case reports on endometrial microbiota and pregnancy outcome: An analysis using 16S rRNA gene sequencing among IVF patients, and trial therapeutic intervention for dysbiotic endometrium.
一项关于子宫内膜微生物群与妊娠结局的初步研究及病例报告：对体外受精患者进行16S rRNA基因测序分析，并对子宫内膜生态失调进行试验性治疗干预。
Reprod Med Biol. 2018 Oct 25;18(1):72-82. doi: 10.1002/rmb2.12250. eCollection 2019 Jan.
4
Vaginal Microbiota and In Vitro Fertilization Outcomes: Development of a Simple Diagnostic Tool to Predict Patients at Risk of a Poor Reproductive Outcome.阴道微生物组与体外受精结局：开发简单诊断工具预测不良妊娠结局风险患者。
J Infect Dis. 2019 May 5;219(11):1809-1817. doi: 10.1093/infdis/jiy744.
5
Systematic Comparison of Bacterial Colonization of Endometrial Tissue and Fluid Samples in Recurrent Miscarriage Patients: Implications for Future Endometrial Microbiome Studies.反复性流产患者的子宫内膜组织和液体样本细菌定植的系统比较：对未来子宫内膜微生物组研究的启示。
Clin Chem. 2018 Dec;64(12):1743-1752. doi: 10.1373/clinchem.2018.289306. Epub 2018 Sep 20.
6
Differential proteomic analysis of endometrial fluid suggests increased inflammation and impaired glucose metabolism in non-implantative IVF cycles and pinpoints PYGB as a putative implantation marker.子宫内膜液的差异蛋白质组学分析表明，非着床性 IVF 周期中炎症增加和葡萄糖代谢受损，并指出 PYGB 是一个潜在的着床标志物。
Hum Reprod. 2018 Oct 1;33(10):1898-1906. doi: 10.1093/humrep/dey274.
7
Relevance of assessing the uterine microbiota in infertility.评估不孕患者子宫微生物组的相关性。
Fertil Steril. 2018 Aug;110(3):337-343. doi: 10.1016/j.fertnstert.2018.04.041.
8
Analysis of endometrial microbiota by 16S ribosomal RNA gene sequencing among infertile patients: a single-center pilot study.通过16S核糖体RNA基因测序对不孕患者子宫内膜微生物群的分析：一项单中心试点研究。
Reprod Med Biol. 2018 May 6;17(3):297-306. doi: 10.1002/rmb2.12105. eCollection 2018 Jul.
9
How uterine microbiota might be responsible for a receptive, fertile endometrium.子宫微生物组如何影响容受性和肥沃的子宫内膜。
Hum Reprod Update. 2018 Jul 1;24(4):393-415. doi: 10.1093/humupd/dmy012.
10
Proteomic pattern of implantative human endometrial fluid in in vitro fertilization cycles.体外受精周期中植入期人子宫内膜液的蛋白质组学模式。
Arch Gynecol Obstet. 2018 Jun;297(6):1577-1586. doi: 10.1007/s00404-018-4753-1. Epub 2018 Apr 10.