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Identification of the human beta-actin enhancer and its binding factor.

作者信息

Kawamoto T, Makino K, Niwa H, Sugiyama H, Kimura S, Amemura M, Nakata A, Kakunaga T

机构信息

Department of Oncogene Research, Osaka University, Japan.

出版信息

Mol Cell Biol. 1988 Jan;8(1):267-72. doi: 10.1128/mcb.8.1.267-272.1988.

DOI:10.1128/mcb.8.1.267-272.1988
PMID:3422098
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC363114/
Abstract

An enhancer of the human beta-actin gene and a factor that specifically interacts with it were detected. A mobility shift assay showed that the factor bound to the 25-base-pair sequence (between +759 and +783 downstream from the cap site) with high specificity. This finding correlated with those of DNase I protection and exonuclease III digestion assays. This binding region of the beta-actin enhancer contained a hyphenated dyad symmetry and an enhancer core-like sequence. In vitro competition experiments indicated that the factor did not bind to the simian virus 40 enhancer core region.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7f7/363114/53cc1bee7df6/molcellb00061-0293-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7f7/363114/d392fd631797/molcellb00061-0290-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7f7/363114/ddb14a074e35/molcellb00061-0291-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7f7/363114/33d3f79763a3/molcellb00061-0292-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7f7/363114/0e6588654750/molcellb00061-0293-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7f7/363114/53cc1bee7df6/molcellb00061-0293-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7f7/363114/d392fd631797/molcellb00061-0290-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7f7/363114/ddb14a074e35/molcellb00061-0291-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7f7/363114/33d3f79763a3/molcellb00061-0292-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7f7/363114/0e6588654750/molcellb00061-0293-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7f7/363114/53cc1bee7df6/molcellb00061-0293-b.jpg

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