Feliu J, Juarez S, Ordoñez A, Garcia-Paredes M L, Gonzalez-Baron M, Montero J M
Department of Internal Medicine, Cuidad Sanitaria La Paz, University Autonoma of Madrid, Spain.
Cancer. 1988 Feb 1;61(3):580-4. doi: 10.1002/1097-0142(19880201)61:3<580::aid-cncr2820610326>3.0.co;2-h.
Acute leukemia was diagnosed in five pregnant patients who received chemotherapy during the course of pregnancy. Three were undergoing chemotherapy at conception. One patient died in the fifth month of pregnancy and the anatomic study of the fetus was normal. Four babies had low birth weights at birth. Of the four one was born prematurely, but without malformations. Later development was normal. The results are reviewed and compared with data from the literature, leading to the conclusion that pregnancy is not an absolute contraindication for cytostatic treatment, except in the first trimester, in which cytostatic treatment should be avoided.
五名在孕期接受化疗的孕妇被诊断为急性白血病。三名在受孕时正在接受化疗。一名患者在怀孕第五个月时死亡，胎儿的解剖学研究正常。四名婴儿出生时体重低。这四名婴儿中有一名早产，但无畸形。后期发育正常。对结果进行了回顾，并与文献数据进行了比较，得出结论：除了在孕早期应避免进行细胞毒性治疗外，怀孕并非细胞毒性治疗的绝对禁忌证。
