Pizzuto J, Aviles A, Noriega L, Niz J, Morales M, Romero F
Cancer Treat Rep. 1980 Apr-May;64(4-5):679-83.
The hematologic and obstetric problems of nine pregnant patients with acute leukemia are analyzed. Seven patients received chemotherapy during various trimesters of pregnancy, four during the first 10 weeks, and there was no evidence of congenital malformations in any of their offspring. Six of nine babies are alive and healthy with a normal growth 2 months to 15 years after birth, one child was stillborn, and two children died 21 and 90 days after birth. These results were compared with others in the literature and the conclusions are that pregnancy is not a contraindication for treatment of acute leukemia, that cytotoxic drugs may not cause congenital malformations, and that the management of pregnant patients with acute leukemia should be carefully planned.
分析了9例急性白血病孕妇的血液学和产科问题。7例患者在孕期不同阶段接受了化疗，其中4例在妊娠前10周接受化疗，其后代均未发现先天性畸形。9例婴儿中有6例在出生后2个月至15岁时存活且健康，生长正常，1例死产，2例在出生后21天和90天死亡。将这些结果与文献中的其他结果进行了比较，得出的结论是，妊娠不是急性白血病治疗的禁忌证，细胞毒性药物可能不会导致先天性畸形，并且应对急性白血病孕妇进行精心的治疗规划。
