Moore T C, Spruck C H, Leduc L E
Department of Surgery, UCLA School of Medicine, Torrance.
Immunology. 1988 Jan;63(1):139-43.
General anaesthesia of sheep with ketamine and xylazine has been found to produce a profound and prolonged depression in lymphocyte traffic through primary peripheral lymph nodes, as mirrored in the output of lymphocytes into efferent lymph. In this study, the depression has been found to be associated with a marked and sustained elevation in prostaglandin E2 (PGE2) levels in efferent lymph. The degree and duration of lymphocyte output depression was found to be modulated (diminished), both in degree and duration, by study-node drainage-area stimulation from prior surgery, inflammation or bacterial immunization. Even when the anaesthesia-associated lymphocyte-output depression was modulated by drainage-area inflammation, the period of lymphocyte-output depression was correlated still with elevated levels of PGE2 in efferent lymph. When drainage-area stimulation was produced by bacterial immunization (killed Salmonella muenchen), the anaesthesia-associated depression in lymphocyte output into efferent lymph (small as well as blast) was accompanied by a depression in antibody output into efferent lymph.
已发现用氯胺酮和赛拉嗪对绵羊进行全身麻醉会使淋巴细胞通过初级外周淋巴结的运输产生深刻而持久的抑制，这在淋巴细胞输出到输出淋巴管中得到体现。在本研究中，已发现这种抑制与输出淋巴管中前列腺素E2（PGE2）水平的显著且持续升高有关。研究发现，来自先前手术、炎症或细菌免疫的研究节点引流区域刺激会在程度和持续时间上调节（减轻）淋巴细胞输出抑制的程度和持续时间。即使麻醉相关的淋巴细胞输出抑制通过引流区域炎症进行调节，淋巴细胞输出抑制期仍与输出淋巴管中PGE2水平升高相关。当通过细菌免疫（灭活的慕尼黑沙门氏菌）产生引流区域刺激时，麻醉相关的输出淋巴管中淋巴细胞（小淋巴细胞以及母细胞）输出抑制伴随着输出淋巴管中抗体输出的抑制。
