同情用药使用头孢地尔治疗由广泛耐药菌引起的骨髓炎。
A compassionate use of cefiderocol to treat osteomyelitis caused by an XDR .
作者信息
Chavda A, Gilchrist M, Samarasinghe D
机构信息
Imperial College Healthcare NHS Trust, St Mary's Hospital, London W2 1NY, UK.
出版信息
JAC Antimicrob Resist. 2021 Jun 15;3(Suppl 1):i18-i20. doi: 10.1093/jacamr/dlab054. eCollection 2021 Jun.
Abstract
We report a 59-year-old male with left leg osteomyelitis caused by an XDR strain following a road traffic accident. Limited treatment options and adverse antimicrobial reaction led to consideration of cefiderocol together with appropriate surgical intervention. Improved bony remodelling over the tibia and fibula was observed with good bony alignment and no adverse features. Physiotherapy support was continued for 4 months following treatment, which resulted in good functional mobility, improved proprioception and full ability to bear weight. This case also adds to multiple reports that describe safe and successful use of cefiderocol to treat MDR, aerobic Gram-negative infections.
摘要
我们报告了一名59岁男性，在道路交通事故后因广泛耐药菌株导致左腿骨髓炎。有限的治疗选择和不良的抗菌反应促使考虑使用头孢地尔，并进行适当的手术干预。观察到胫骨和腓骨的骨重塑有所改善，骨排列良好且无不良特征。治疗后持续进行了4个月的物理治疗支持，结果功能活动良好，本体感觉改善，完全能够负重。该病例也补充了多篇描述头孢地尔安全成功用于治疗多重耐药需氧革兰氏阴性菌感染的报告。
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