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病例报告：用头孢地尔成功救治广泛耐药性骨髓炎

Case Report: Successful Rescue Therapy of Extensively Drug-Resistant Osteomyelitis With Cefiderocol.

作者信息

Dagher Michael, Ruffin Felicia, Marshall Steven, Taracila Magdalena, Bonomo Robert A, Reilly Rachel, Fowler Vance G, Thaden Joshua T

机构信息

Division of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina, USA.

Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.

出版信息

Open Forum Infect Dis. 2020 May 5;7(5):ofaa150. doi: 10.1093/ofid/ofaa150. eCollection 2020 May.

DOI:10.1093/ofid/ofaa150
PMID:32494581
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7252278/
Abstract

Cefiderocol is a novel catechol siderophore cephalosporin antibiotic developed to treat resistant gram-negative infections. We describe its successful use as rescue therapy, combined with surgical debridement, to treat a patient with osteomyelitis due to extensively drug-resistant Bacterial whole-genome sequencing identified the strain and antibiotic resistance determinants.

摘要

头孢地尔是一种新型儿茶酚铁载体头孢菌素抗生素，用于治疗耐药革兰氏阴性菌感染。我们描述了其作为挽救疗法与手术清创术联合使用，成功治疗一名因广泛耐药菌引起骨髓炎患者的情况。细菌全基因组测序鉴定出了该菌株及抗生素耐药决定因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fbd/7252278/b4071bc36699/ofaa150f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fbd/7252278/b4071bc36699/ofaa150f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fbd/7252278/b4071bc36699/ofaa150f0001.jpg

相似文献

1
Case Report: Successful Rescue Therapy of Extensively Drug-Resistant Osteomyelitis With Cefiderocol.病例报告：用头孢地尔成功救治广泛耐药性骨髓炎
Open Forum Infect Dis. 2020 May 5;7(5):ofaa150. doi: 10.1093/ofid/ofaa150. eCollection 2020 May.
2
Erratum to: The role of the first siderophore cephalosporin Fetcroja (cefiderocol) in UK clinical practice: introduction; Antibiotic resistance during and beyond COVID-19; An introduction to the core data for cefiderocol with reflections for a possible role within UK clinical practice; A compassionate use of cefiderocol to treat osteomyelitis caused by an XDR ; Compassionate use of cefiderocol for carbapenem-resistant prosthetic joint infection; An overview from the author of 'Cefiderocol as rescue therapy for and other carbapenem-resistant Gram-negative infections in intensive care unit patients'.勘误：《第一代铁载体头孢菌素费克罗嘉（头孢地尔）在英国临床实践中的作用：引言》；新冠疫情期间及之后的抗生素耐药性；头孢地尔核心数据介绍及对其在英国临床实践中可能作用的思考；同情使用头孢地尔治疗广泛耐药菌引起的骨髓炎；同情使用头孢地尔治疗耐碳青霉烯类假体关节感染；《头孢地尔作为重症监护病房患者耐碳青霉烯类及其他革兰氏阴性菌感染的挽救疗法》作者概述。
JAC Antimicrob Resist. 2021 Aug 28;3(3):dlab109. doi: 10.1093/jacamr/dlab109. eCollection 2021 Sep.
3
Erratum to: The role of the first siderophore cephalosporin Fetcroja (cefiderocol) in UK clinical practice: introduction; An introduction to the core data for cefiderocol with reflections for a possible role within UK clinical practice; A compassionate use of cefiderocol to treat osteomyelitis caused by an XDR ; Compassionate use of cefiderocol for carbapenem-resistant prosthetic joint infection; An overview from the author of 'Cefiderocol as rescue therapy for and other carbapenem-resistant Gram-negative infections in intensive care unit patients'.勘误：首次出现的铁载体头孢菌素Fetcroja（头孢地尔）在英国临床实践中的作用：引言；头孢地尔核心数据介绍及对其在英国临床实践中可能作用的思考；头孢地尔 compassionate use治疗XDR引起的骨髓炎；头孢地尔 compassionate use治疗耐碳青霉烯类人工关节感染；《头孢地尔作为重症监护病房患者耐碳青霉烯类及其他革兰氏阴性菌感染的挽救治疗》作者概述 。
JAC Antimicrob Resist. 2021 Aug 28;3(3):dlab110. doi: 10.1093/jacamr/dlab110. eCollection 2021 Sep.
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In Vitro Antimicrobial Activity of the Siderophore Cephalosporin Cefiderocol against Strains Recovered from Clinical Samples.铁载体头孢菌素头孢地尔对临床样本分离菌株的体外抗菌活性
Antibiotics (Basel). 2021 Oct 27;10(11):1309. doi: 10.3390/antibiotics10111309.
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Cefiderocol: A Siderophore Cephalosporin with Activity Against Carbapenem-Resistant and Multidrug-Resistant Gram-Negative Bacilli.头孢地尔：一种具有抗碳青霉烯类和多药耐药革兰氏阴性杆菌活性的铁载体头孢菌素。
Drugs. 2019 Feb;79(3):271-289. doi: 10.1007/s40265-019-1055-2.
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Compassionate use of cefiderocol for carbapenem-resistant prosthetic joint infection.头孢地尔在耐碳青霉烯类假体关节感染中的同情用药
JAC Antimicrob Resist. 2021 Jun 15;3(Suppl 1):i21-i24. doi: 10.1093/jacamr/dlab055. eCollection 2021 Jun.
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Cefiderocol-associated brown chromaturia.头孢地尔洛相关的棕色尿色。
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引用本文的文献

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Real-Life Cefiderocol Use in Bone and Joint Infection: A French National Cohort.头孢地尔在骨与关节感染中的实际应用：一项法国全国队列研究。
Antibiotics (Basel). 2025 Apr 8;14(4):388. doi: 10.3390/antibiotics14040388.
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Are cefiderocol or sulbactam/durlobactam better than alternative best available treatment for infection by carbapenem-resistant A. baumannii? A systematic literature review.头孢地尔或舒巴坦/度洛巴坦在治疗耐碳青霉烯类鲍曼不动杆菌感染方面是否优于其他最佳可用治疗方法？一项系统文献综述。
Infection. 2025 Apr 7. doi: 10.1007/s15010-025-02527-7.
3
Antimicrobial Treatment Options for Multidrug Resistant Gram-Negative Pathogens in Bone and Joint Infections.

本文引用的文献

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Long-Term Compassionate Use of Cefiderocol To Treat Chronic Osteomyelitis Caused by Extensively Drug-Resistant Pseudomonas aeruginosa and Extended-Spectrum-β-Lactamase-Producing Klebsiella pneumoniae in a Pediatric Patient.头孢地尔长期同情用药治疗一名儿科患者由广泛耐药铜绿假单胞菌和产超广谱β-内酰胺酶肺炎克雷伯菌引起的慢性骨髓炎
Antimicrob Agents Chemother. 2020 Mar 24;64(4). doi: 10.1128/AAC.01872-19.
2
Evolution of the antimicrobial resistance rates in clinical isolates of Pseudomonas aeruginosa causing invasive infections in the south of Spain.西班牙南部引起侵袭性感染的铜绿假单胞菌临床分离株的抗菌药物耐药率演变。
Enferm Infecc Microbiol Clin (Engl Ed). 2020 Apr;38(4):150-154. doi: 10.1016/j.eimc.2019.06.009. Epub 2019 Aug 7.
3
骨与关节感染中耐多药革兰氏阴性病原体的抗菌治疗选择
Pathogens. 2025 Feb 1;14(2):130. doi: 10.3390/pathogens14020130.
4
In vitro resistance development gives insights into molecular resistance mechanisms against cefiderocol.体外耐药性发展使人们深入了解对头孢地尔罗耐药的分子耐药机制。
J Antibiot (Tokyo). 2024 Nov;77(11):757-767. doi: 10.1038/s41429-024-00762-y. Epub 2024 Jul 30.
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Compassionate use of cefiderocol in a complex case of extensively drug-resistant Acinetobacter baumannii fracture-related infection: a comprehensive approach and multidisciplinary management.头孢地尔在一例广泛耐药鲍曼不动杆菌骨折相关感染复杂病例中的同情用药：综合方法与多学科管理
Infection. 2024 Dec;52(6):2487-2493. doi: 10.1007/s15010-024-02294-x. Epub 2024 May 15.
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Case Report: Hip arthroplasty after fracture-related joint infection caused by extensively drug-resistant .病例报告：广泛耐药菌所致骨折相关关节感染后的髋关节置换术
Front Surg. 2024 Feb 27;11:1363298. doi: 10.3389/fsurg.2024.1363298. eCollection 2024.
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Successful outpatient parenteral antibiotic therapy with cefiderocol for osteomyelitis caused by multi-drug resistant Gram-negative bacteria: a case report.使用头孢地尔进行门诊胃肠外抗生素治疗耐多药革兰氏阴性菌引起的骨髓炎成功：病例报告
JAC Antimicrob Resist. 2024 Feb 7;6(1):dlae015. doi: 10.1093/jacamr/dlae015. eCollection 2024 Feb.
8
Cefiderocol and Sulbactam-Durlobactam against Carbapenem-Resistant .头孢地尔和舒巴坦-度洛巴坦治疗耐碳青霉烯类感染
Antibiotics (Basel). 2023 Dec 14;12(12):1729. doi: 10.3390/antibiotics12121729.
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Carbapenem-Resistant spp Infection in Critically Ill Patients With Limited Treatment Options: A Descriptive Study of Cefiderocol Therapy During the COVID-19 Pandemic.治疗选择有限的重症患者中的耐碳青霉烯类菌感染：COVID-19大流行期间头孢地尔治疗的描述性研究
Open Forum Infect Dis. 2023 Jul 4;10(7):ofad329. doi: 10.1093/ofid/ofad329. eCollection 2023 Jul.
10
The Role of Novel Antibiotics in the Management of Diabetic Foot Infection.新型抗生素在糖尿病足感染治疗中的作用
Diabetes Ther. 2023 Feb;14(2):251-263. doi: 10.1007/s13300-022-01357-2. Epub 2022 Dec 24.
Successful treatment with cefiderocol for compassionate use in a critically ill patient with XDR Acinetobacter baumannii and KPC-producing Klebsiella pneumoniae: a case report.头孢地尔在一名患有广泛耐药鲍曼不动杆菌和产KPC肺炎克雷伯菌的重症患者中同情用药的成功治疗：一例报告
J Antimicrob Chemother. 2019 Nov 1;74(11):3399-3401. doi: 10.1093/jac/dkz318.
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Cefiderocol versus imipenem-cilastatin for the treatment of complicated urinary tract infections caused by Gram-negative uropathogens: a phase 2, randomised, double-blind, non-inferiority trial.头孢地尔优于亚胺培南西司他丁钠治疗革兰氏阴性尿路病原体引起的复杂性尿路感染：一项 2 期、随机、双盲、非劣效性试验。
Lancet Infect Dis. 2018 Dec;18(12):1319-1328. doi: 10.1016/S1473-3099(18)30554-1. Epub 2018 Oct 25.
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Compassionate Use of Cefiderocol as Adjunctive Treatment of Native Aortic Valve Endocarditis Due to Extremely Drug-resistant Pseudomonas aeruginosa.头孢地尔罗治疗由极耐药铜绿假单胞菌引起的原发性主动脉瓣心内膜炎的同情使用。
Clin Infect Dis. 2019 May 17;68(11):1932-1934. doi: 10.1093/cid/ciy963.
6
Cefiderocol (S-649266), A new siderophore cephalosporin exhibiting potent activities against Pseudomonas aeruginosa and other gram-negative pathogens including multi-drug resistant bacteria: Structure activity relationship.头孢地尔罗（S-649266），一种新型的铁载体头孢菌素，对铜绿假单胞菌和其他革兰氏阴性病原体具有强大的活性，包括多药耐药菌：构效关系。
Eur J Med Chem. 2018 Jul 15;155:847-868. doi: 10.1016/j.ejmech.2018.06.014. Epub 2018 Jun 8.
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Interdependence between iron acquisition and biofilm formation in Pseudomonas aeruginosa.铜绿假单胞菌中铁的获取与生物膜形成的相互依赖性。
J Microbiol. 2018 Jul;56(7):449-457. doi: 10.1007/s12275-018-8114-3. Epub 2018 Jun 14.
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Pharmacokinetics, Safety, and Tolerability of Cefiderocol, a Novel Siderophore Cephalosporin for Gram-Negative Bacteria, in Healthy Subjects.健康受试者中新型铁载体头孢菌素头孢地尔的药代动力学、安全性和耐受性。
Antimicrob Agents Chemother. 2018 Feb 23;62(3). doi: 10.1128/AAC.02163-17. Print 2018 Mar.
9
Phenotypic and genotypic detection of β-lactamases in Acinetobacter spp. isolates recovered from Lebanese patients over a 1-year period.在过去一年中，从黎巴嫩患者中分离出的不动杆菌属菌株中β-内酰胺酶的表型和基因型检测。
J Glob Antimicrob Resist. 2018 Mar;12:107-112. doi: 10.1016/j.jgar.2017.09.016. Epub 2017 Oct 3.
10
Activity of the novel siderophore cephalosporin cefiderocol against multidrug-resistant Gram-negative pathogens.新型铁载体头孢菌素头孢地尔的活性对多重耐药革兰氏阴性病原体。
Eur J Clin Microbiol Infect Dis. 2017 Dec;36(12):2319-2327. doi: 10.1007/s10096-017-3063-z. Epub 2017 Jul 26.