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Possible association of human growth hormone treatment with an occurrence of acute myeloblastic leukemia with an inversion of chromosome 3 in a child of pituitary dwarfism.

作者信息

Endo M, Kaneko Y, Shikano T, Minami H, Chino J

机构信息

Department of Pediatrics, Hakodate-Chuo Hospital, Japan.

出版信息

Med Pediatr Oncol. 1988;16(1):45-7. doi: 10.1002/mpo.2950160111.

DOI:10.1002/mpo.2950160111
PMID:3422334
Abstract

An 11-yr-old girl, who had been treated with human growth hormone (h-GH) for 31 months, developed acute myeloblastic leukemia with an inv(3)(q21q26). Since GH has been suggested to influence the genesis of leukemia, and the inversion 3 has been reported only in adult leukemia patients, the GH treatment may have caused the development of leukemia or accelerated the proliferation of the leukemia cells.

摘要

相似文献

1
Possible association of human growth hormone treatment with an occurrence of acute myeloblastic leukemia with an inversion of chromosome 3 in a child of pituitary dwarfism.
Med Pediatr Oncol. 1988;16(1):45-7. doi: 10.1002/mpo.2950160111.
2
Acute lymphoblastic leukemia in a patient with pituitary dwarfism under treatment with growth hormone.
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Development of acute myeloid leukemia associated with Ph-negative clone with inv(3)(q21q26) during imatinib therapy for chronic myeloid leukemia.慢性髓性白血病伊马替尼治疗期间伴inv(3)(q21q26)的Ph阴性克隆相关急性髓性白血病的发生
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Paracentric inv(3)(q21q26) in acute myeloblastic leukemia (M2) with normal thrombopoiesis.急性髓细胞白血病（M2型）伴正常血小板生成的臂内倒位inv(3)(q21q26)
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Leukemia and other malignancies among GH users.生长激素使用者中的白血病及其他恶性肿瘤。
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The occurrence of acute lymphoblastic leukemia shortly after the cessation of human growth hormone therapy.在停止人生长激素治疗后不久发生急性淋巴细胞白血病。
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Correlation of cytogenetic findings with clinical features in 18 patients with inv(3)(q21q26) or t(3;3)(q21;q26).18例inv(3)(q21q26)或t(3;3)(q21;q26)患者细胞遗传学结果与临床特征的相关性
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[Treatment of children with short stature with human growth hormone and its potential risks].
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Chromosome abnormalities in acute leukemia: its clinical implications and age of onset.急性白血病中的染色体异常：其临床意义及发病年龄
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