State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, 430070, China.
Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, Hubei, 430070, China.
Future Microbiol. 2021 Jul;16:721-729. doi: 10.2217/fmb-2020-0232. Epub 2021 Jul 5.
This study aims to develop a subunit vaccine with high cross-protection for . Four-week-old female BALB/c mice were first immunized with a single and mixed protein. Various indicators, such as antibody titers and various cytokine levels, were further analyzed. The results showed that purified recombinant proteins IF-2 and 1022 had a good protective effect against lethal doses of serotype 2 and serotype 9. This study showed immunization with recombinant proteins. IF-2 and 1022 can enhance cross-protection against serotypes 2 and 9.
本研究旨在开发一种具有高度交叉保护作用的亚单位疫苗。首先用单一和混合蛋白对 4 周龄雌性 BALB/c 小鼠进行免疫。进一步分析了抗体滴度和各种细胞因子水平等各种指标。结果表明，纯化的重组蛋白 IF-2 和 1022 对 2 型和 9 型血清型的致死剂量具有良好的保护作用。本研究表明，用重组蛋白免疫。IF-2 和 1022 可以增强对 2 型和 9 型的交叉保护作用。
