Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Curr Opin Organ Transplant. 2021 Aug 1;26(4):419-423. doi: 10.1097/MOT.0000000000000892.
Persons living with HIV (PLWH) have a life expectancy that is nearly equivalent to the general population, and thus are facing health conditions associated with normal aging as well as long-term HIV infection. End-organ disease is associated with significant morbidity and mortality and solid organ transplantation (SOT) may be a viable option for many PLWH. We review the history and recent updates in SOT in PLWH, specifically focusing on HIV-to-HIV transplantation.
Following promising data out of South Africa and to expand the donor pool, the United States passed the HIV Organ Procurement Equity (HOPE) Act, allowing for HIV-to-HIV SOT. Preliminary data to date, especially in HIV-to-HIV kidney transplantation, suggest overall excellent patient and graft survival outcomes with no HIV breakthrough infection.
Preliminary HIV D+R+ SOT data to date suggest promising patient outcomes and no significant adverse events to recipients or living donors. This is an important step in expanding the donor pool and increasing opportunity for SOT in PLWH.
感染人类免疫缺陷病毒（HIV）的患者的预期寿命与普通人群相当，因此他们面临着与正常衰老以及长期 HIV 感染相关的健康问题。靶器官疾病与较高的发病率和死亡率相关，实体器官移植（SOT）可能是许多 HIV 感染者的可行选择。我们回顾了 HIV 感染者 SOT 的历史和最新进展，特别是重点关注 HIV 对 HIV 的移植。
继南非的初步数据以及扩大供体库之后，美国通过了《艾滋病毒器官采购公平法》（HOPE 法案），允许进行 HIV 对 HIV 的 SOT。迄今为止的初步数据，特别是在 HIV 对 HIV 肾移植中，整体上患者和移植物的存活率非常高，没有 HIV 突破性感染。
迄今为止，HIV D+R+SOT 的初步数据表明患者的预后非常有希望，并且没有对受者或活体供者产生重大不良事件。这是扩大供体库和增加 HIV 感染者 SOT 机会的重要一步。
