Centre on Theoretical Problems in Physical and Chemical Pharmacology, Russian Academy of Sciences, Moscow, Russia.
Timpharm LTD, Moscow, Russia.
Behav Brain Res. 2021 Aug 27;412:113445. doi: 10.1016/j.bbr.2021.113445. Epub 2021 Jul 2.
A decreased H receptor activity is observed in the anterior cingulate cortex (aCgCx) of depressed patients. The role of this abnormality in the development of depression-related processes is unstudied. We examined the influence of a decreased brain H receptor activity on rat behavior in the sucrose preference test. The H receptor deficit was simulated by injection of an H antagonist into the aCgCx; also, two aCgCx projection areas, lateral and medial entorhinal cortices were examined. A blockade of H-receptors in the aCgCx and lateral entorhinal cortex (LEntCx) significantly reduced sucrose preference. These findings suggest the existence of H receptor-mediated aCgCx-LEntCx circuitry mechanism regulating anhedonic-like behavior in rats. The presented data suggest that H receptor-mediated processes might be a therapeutic target in depressive disorders.
在抑郁患者的前扣带皮层（aCgCx）中观察到 H 受体活性降低。这种异常在抑郁相关过程的发展中的作用尚未研究。我们研究了 H 受体活性降低对蔗糖偏好测试中大鼠行为的影响。通过向 aCgCx 注射 H 拮抗剂来模拟 H 受体缺陷；此外，还检查了两个 aCgCx 投射区域，外侧和内侧内嗅皮层。aCgCx 和外侧内嗅皮层（LEntCx）中 H 受体的阻断显著降低了蔗糖偏好。这些发现表明存在 H 受体介导的调节大鼠快感缺失样行为的 aCgCx-LEntCx 回路机制。所提供的数据表明，H 受体介导的过程可能是治疗抑郁障碍的靶点。
