Bandim Health Project, INDEPTH Network, Bissau, Guinea-Bissau; Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark; GloHAU, Centre for Global Health, Department of Public Health, Aarhus University, Aarhus, Denmark.
Bandim Health Project, INDEPTH Network, Bissau, Guinea-Bissau; GloHAU, Centre for Global Health, Department of Public Health, Aarhus University, Aarhus, Denmark.
Int J Infect Dis. 2021 Aug;109:123-128. doi: 10.1016/j.ijid.2021.06.062. Epub 2021 Jul 2.
Tuberculosis (TB) is associated with a number of non-communicable co-morbidities, which can complicate treatment and impair outcome. The aim of this study was to assess the impact of hypertension on disease severity, treatment outcome and survival in a cohort of patients with TB.
A retrospective cohort study was conducted in Guinea-Bissau. Patients newly diagnosed with TB between November 2003 and June 2016 were included. Hypertension was defined as blood pressure ≥140/90 mmHg. Disease severity was assessed using the Bandim TBscore. Survival was assessed at the end of treatment and 2 years after treatment initiation.
In total, 1544 patients were included in this study. Hypertension was present in 12.8% of patients at inclusion. Patients with hypertension had slightly less severe TB, but were less likely to have a successful treatment outcome and had 64% higher mortality at 2-year follow-up (adjusted hazard ratio 1.64, 95% confidence interval 1.15-2.34). Mortality rates were highest in hypertensive female patients and patients aged ≥ 45 years.
Patients with high blood pressure at the start of TB treatment had a higher mortality rate at 2-year follow-up. Mortality rates were highest in hypertensive females and patients aged ≥ 45 years.
结核病（TB）与许多非传染性合并症有关，这些合并症可能使治疗复杂化并影响治疗结果。本研究的目的是评估高血压对一组结核病患者的疾病严重程度、治疗结果和生存的影响。
在几内亚比绍进行了一项回顾性队列研究。2003 年 11 月至 2016 年 6 月期间新诊断为结核病的患者被纳入研究。高血压定义为血压≥140/90mmHg。使用 Bandim TBscore 评估疾病严重程度。在治疗结束时和治疗开始后 2 年评估生存情况。
本研究共纳入 1544 名患者。纳入时，12.8%的患者存在高血压。患有高血压的患者结核病的严重程度略低，但治疗结果成功的可能性较小，并且在 2 年随访时死亡率高出 64%（调整后的危险比 1.64，95%置信区间 1.15-2.34）。高血压女性患者和年龄≥45 岁的患者死亡率最高。
在开始结核病治疗时血压升高的患者在 2 年随访时的死亡率更高。高血压女性和年龄≥45 岁的患者的死亡率最高。
