Haraldsdottir Thorny L, Rudolf Frauke, Bjerregaard-Andersen Morten, Joaquím Luis Carlos, Stochholm Kirstine, Gomes Victor F, Beck-Nielsen Henning, Ostergaard Lars, Aaby Peter, Wejse Christian
Bandim Health Project, Apartado 861, 1004 Bissau Codex, Guinea-Bissau Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark
Bandim Health Project, Apartado 861, 1004 Bissau Codex, Guinea-Bissau Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.
Trans R Soc Trop Med Hyg. 2015 Jun;109(6):400-7. doi: 10.1093/trstmh/trv030. Epub 2015 Apr 26.
Data regarding the association between diabetes mellitus (DM) and tuberculosis (TB) in Africa are scare. We did a DM screening survey among TB patients and non-TB controls in Guinea-Bissau.
The study was conducted at the Bandim Health Project (BHP) in the capital Bissau. From July 2010 to July 2011, newly diagnosed TB cases were identified through a TB notification system. Concurrently, non-TB controls were selected randomly from the BHP's demographic surveillance database and visited at home. Participants were tested using fasting blood glucose (FBG) measurements. DM was diagnosed as FBG ≥ 7 mmol/l. Our survey was linked to the patient database at the only existing Diabetes Clinic in Bissau.
TB patients (n=110) were older than the controls (n=572) (35 vs 31 years; p=0.02), more often male (55% vs 37%; p<0.001) and had a lower body mass index (18.7 vs 24.2 kg/m(2); p<0.001). The prevalence of DM was 2.8% (3/107) for TB patients and 2.1% (11/531) for controls (p=0.64). Excluding two controls already receiving anti-diabetic treatment, the prevalence of DM was 2.8% (3/107) vs 1.7% (9/529) (p=0.44).
The prevalence of DM was low, also among TB patients. No association between DM and TB was found.
非洲关于糖尿病（DM）与结核病（TB）之间关联的数据匮乏。我们在几内亚比绍的结核病患者和非结核病对照人群中开展了一项糖尿病筛查调查。
该研究在首都比绍的班迪姆健康项目（BHP）进行。2010年7月至2011年7月，通过结核病通报系统识别新诊断的结核病病例。同时，从BHP的人口监测数据库中随机选择非结核病对照人群，并进行家访。参与者接受空腹血糖（FBG）检测。糖尿病的诊断标准为FBG≥7 mmol/l。我们的调查与比绍唯一一家糖尿病诊所的患者数据库相关联。
结核病患者（n = 110）比对照人群（n = 572）年龄更大（35岁对31岁；p = 0.02），男性比例更高（55%对37%；p < 0.001），体重指数更低（18.7对24.2 kg/m²；p < 0.001）。结核病患者中糖尿病的患病率为2.8%（3/107），对照人群中为2.1%（11/531）（p = 0.64）。排除两名已接受抗糖尿病治疗的对照者后，糖尿病的患病率为2.8%（3/107）对1.7%（9/529）（p = 0.44）。
糖尿病的患病率较低，在结核病患者中亦是如此。未发现糖尿病与结核病之间存在关联。
