Associate Chief Physician, Department of Geriatric Psychiatry in Huzhou Third Municipal Hospital, The Affiliated Hospital of Huzhou University, China.
Doctor-In-Charge, Department of Geriatric Psychiatry in Huzhou Third Municipal Hospital, The Affiliated Hospital of Huzhou University, China.
Scott Med J. 2021 Aug;66(3):134-141. doi: 10.1177/00369330211027450. Epub 2021 Jul 5.
Sleep disturbances are a severe problem among patients with Alzheimer's disease (AD). By evaluating sleep quality in mild-to-moderate AD patients, this study aimed to assess the effects of multi-disciplinary team (MDT) in reducing the incidence of adverse reactions of AD patients. The reduction in the incidence of adverse reactions to predict multi-disciplinary team (MDT) treatment effects.
This study included 60 mild-to-moderate AD patients with sleep problems when hospitalized in Huzhou Third Municipal Hospital. The patients were randomly distributed into two groups, routine and MDT treatments. The cognitive functions, sleep conditions, and psycho-behavioral symptoms were compared between both the groups. Cognitive function declined significantly between pretherapy and follow-up in the routine treatment group (MMSE: t = -7.961, < 0.001; MoCA: t = -4.672, < 0.001). There was a significant decline in drowsiness in the MDT group compared to that in the routine treatment group (χ = 4.320, = 0.038). Sleep quality improved significantly during the follow-up in the MDT treatment group (t = 6.098, < 0.001). The results of the Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA) among family caregivers (FCGs) demonstrated that MDT treatment could alleviate caregivers' depression (t = -2.867, = 0.042), and routine treatment can worsen their anxiety (t = 3.258, = 0.003).
The MDT treatment method as an effective and meaningful therapy can help mitigate the suffering of patients with AD and FCGs.
睡眠障碍是阿尔茨海默病（AD）患者的严重问题。通过评估轻度至中度 AD 患者的睡眠质量，本研究旨在评估多学科团队（MDT）降低 AD 患者不良反应发生率的效果。降低不良反应发生率可预测多学科团队（MDT）治疗效果。
本研究纳入了 60 例在湖州市第三人民医院住院时伴有睡眠问题的轻度至中度 AD 患者。患者被随机分为常规治疗组和 MDT 治疗组。比较两组患者的认知功能、睡眠状况和心理行为症状。常规治疗组在治疗前和随访时认知功能明显下降（MMSE：t=-7.961， < 0.001；MoCA：t=-4.672， < 0.001）。MDT 组与常规治疗组相比，嗜睡程度明显下降（χ = 4.320， = 0.038）。MDT 治疗组睡眠质量在随访期间明显改善（t = 6.098， < 0.001）。家庭照顾者（FCGs）的汉密尔顿抑郁量表（HAMD）和汉密尔顿焦虑量表（HAMA）结果表明，MDT 治疗可以减轻照顾者的抑郁（t=-2.867， = 0.042），而常规治疗会加重他们的焦虑（t=3.258， = 0.003）。
MDT 治疗方法是一种有效且有意义的治疗方法，可以帮助减轻 AD 患者和 FCGs 的痛苦。
