Department of Pharmacy, Chengdu Fifth People's Hospital, Chengdu University of TCM, Chengdu, China.
Department of Interventional Therapy, Chengdu Fifth People's Hospital, Chengdu University of TCM, Chengdu, China.
Expert Rev Gastroenterol Hepatol. 2021 Aug;15(8):879-890. doi: 10.1080/17474124.2021.1949288. Epub 2021 Jul 7.
: Hepatic stellate cells (HSCs) are essential for physiological homeostasis of the liver extracellular matrix (ECM). Excessive transdifferentiation of HSC from a quiescent to an activated phenotype contributes to disrupt this balance and can lead to liver fibrosis. Accumulating evidence has suggested that nuclear receptors (NRs) are involved in the regulation of HSC activation, proliferation, and function. Therefore, these NRs may be therapeutic targets to balance ECM homeostasis and inhibit HSC activation in liver fibrosis.: In this review, the authors summarized the recent progress in the understanding of the regulatory role of NRs in HSCs and their potential as drug targets in liver fibrosis.: NRs are still potential therapy targets for inhibiting HSCs activation and liver fibrosis. However, the development of NRs agonists or antagonists to inhibit HSCs requires fully consideration of systemic effects.
: 肝星状细胞（HSCs）对于肝脏细胞外基质（ECM）的生理稳态至关重要。HSC 从静止状态向激活表型的过度转化会破坏这种平衡，并导致肝纤维化。越来越多的证据表明，核受体（NRs）参与 HSC 激活、增殖和功能的调节。因此，这些 NRs 可能是治疗靶点，以平衡 ECM 稳态并抑制肝纤维化中的 HSC 激活。: 在这篇综述中，作者总结了近年来对 NRs 在 HSCs 中的调节作用及其作为肝纤维化药物靶点的潜在作用的理解进展。: NRs 仍然是抑制 HSCs 激活和肝纤维化的潜在治疗靶点。然而，开发抑制 HSCs 的 NRs 激动剂或拮抗剂需要充分考虑全身效应。
