Department of Children's Health Care, Guangdong Women and Children Hospital, Guangzhou Medical University, Guangzhou, China.
J Matern Fetal Neonatal Med. 2022 Dec;35(25):7231-7237. doi: 10.1080/14767058.2021.1946781. Epub 2021 Jul 5.
The effect of maternal vitamin D levels on the birth weight of the offspring remains controversial, as the results are inconsistent between different populations. This large retrospective cohort study aimed to assess the relationship between maternal vitamin D levels and birth weight of neonates in southern China.
Serum samples were collected from 10,586 Chinese women at 13-27 weeks of pregnancy, and the 25-hydroxyvitamin D (25(OH)D) level of the participants was assessed. Using the INTERGROWTH-21st standards, the offspring were classified into three groups based on their gestational age and birth weight, which were small for gestational age (SGA), appropriate for gestational age (AGA), and large for gestational age (LGA). The differences in vitamin D levels among the different groups were compared, and their correlation with newborn birth weight was analyzed.
The average maternal vitamin D concentration was 61.1 nmol/L. The 25(OH)D concentrations were 50-75 nmol/L, 25-50 nmol/L and below 25 nmol/L in 45.5%, 29.5%, and 1.6% of the participants, respectively. No significant differences were observed in the vitamin D levels between the three groups. With the increase in 25(OH)D levels, the risk of SGA and LGA tended to increase and decrease, respectively. AGA was not affected by the 25(OH)D levels. The results of the curve fitting and threshold effect analyses did not support the correlation between vitamin D levels and SGA or LGA. Based on the univariate prediction model and the model adjusted for risk factors, the area under the curve was extremely small. Thus, 25(OH)D levels are not an effective predictor of SGA and LGA.
Low maternal vitamin D levels were not associated with SGA or LGA.
母体维生素 D 水平对后代出生体重的影响仍存在争议，因为不同人群的结果不一致。本大规模回顾性队列研究旨在评估中国南方孕妇维生素 D 水平与新生儿出生体重之间的关系。
在妊娠 13-27 周时采集了 10586 名中国妇女的血清样本，并评估了参与者的 25-羟维生素 D（25（OH）D）水平。根据 INTERGROWTH-21st 标准，根据胎龄和出生体重将后代分为小胎龄儿（SGA）、适于胎龄儿（AGA）和大胎龄儿（LGA）三组。比较了不同组间维生素 D 水平的差异，并分析了其与新生儿出生体重的相关性。
平均母体维生素 D 浓度为 61.1 nmol/L。25（OH）D 浓度分别为 50-75 nmol/L、25-50 nmol/L 和低于 25 nmol/L 的参与者分别占 45.5%、29.5%和 1.6%。三组间维生素 D 水平无显著差异。随着 25（OH）D 水平的增加，SGA 和 LGA 的风险分别呈上升和下降趋势。AGA 不受 25（OH）D 水平的影响。曲线拟合和阈值效应分析的结果不支持维生素 D 水平与 SGA 或 LGA 之间的相关性。基于单变量预测模型和调整了危险因素的模型，曲线下面积极小。因此，25（OH）D 水平不是 SGA 和 LGA 的有效预测指标。
母体维生素 D 水平低与 SGA 或 LGA 无关。
