姜黄素新型给药系统：改善神经疾病治疗效果的应用。
Novel Drug Delivery System for Curcumin: Implementation to Improve Therapeutic Efficacy against Neurological Disorders.
机构信息
Department of Pharmaceutical Sciences, Pharmacognosy Division, University of Kashmir, Hazratbal, Srinagar- 190006, Kashmir, India.
Department of Pharmaceutical Sciences, Pharmaceutical Chemistry Division, University of Kashmir, Hazratbal, Srinagar-190006, Kashmir, India.
出版信息
Comb Chem High Throughput Screen. 2022;25(4):607-615. doi: 10.2174/1386207324666210705114058.
BACKGROUND
Curcumin, a hydrophobic polyphenolic compound present in Curcuma longa Linn. (Turmeric), has been used to improve various neurodegenerative conditions, including Amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, Prion disease, stroke, anxiety, depression, and ageing. However, the Blood-Brain Barrier (BBB) impedes the delivery of curcumin to the brain, limiting its therapeutic potential.
OBJECTIVE/AIM: This review summarises the recent advances towards the therapeutic efficacy of curcumin along with various novel strategies to overcome its poor bioavailability across the bloodbrain barrier.
METHODS
The data for the compilation of this review work were searched in PubMed Scopus, Google Scholar, and Science Direct.
RESULTS
Various approaches have been opted to expedite the delivery of curcumin across the blood-brain barrier, including liposomes, micelles, polymeric nanoparticles, exosomes, dualtargeting nanoparticles, etc. Conclusion: The review also summarises the numerous toxicological studies and the role of curcumin in CNS disorders.
背景
姜黄素是姜黄属植物（姜黄）中存在的一种疏水性多酚化合物，已被用于改善各种神经退行性疾病，包括肌萎缩侧索硬化症、多发性硬化症、帕金森病、朊病毒病、中风、焦虑、抑郁和衰老。然而，血脑屏障（BBB）阻碍了姜黄素向大脑的传递，限制了其治疗潜力。
目的/目的：本综述总结了姜黄素在治疗功效方面的最新进展，以及各种克服其在血脑屏障中生物利用度差的新策略。
方法
本综述工作的编译数据在 PubMed Scopus、Google Scholar 和 Science Direct 中进行了搜索。
结果
已经选择了各种方法来加速姜黄素穿过血脑屏障的传递，包括脂质体、胶束、聚合物纳米粒、外泌体、双靶向纳米粒等。
结论
综述还总结了许多毒理学研究以及姜黄在中枢神经系统疾病中的作用。
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