Obeid Mohammad A, Alsaadi Manal, Aljabali Alaa A
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Yarmouk University, Irbid, Jordan.
Department of Industrial Pharmacy, Faculty of Pharmacy, University of Tripoli, Tripoli, Libya.
J Liposome Res. 2023 Mar;33(1):53-64. doi: 10.1080/08982104.2022.2086567. Epub 2022 Jun 14.
Curcumin is a natural component extracted from the rhizomes of turmeric (), a natural plat with known medicinal uses for more than 4000 years. Most turmeric therapeutic effects are attributed to curcumin, a yellow-coloured extract. Curcumin has received considerable attention due to its biological activities, such as its use in arthritis, liver and neurodegenerative diseases, obesity, and several types of cancers. Most of these curcumin therapeutic activities are related to its antioxidant and anti-inflammatory effects. However, the clinical application of curcumin is hampered by some limitations that prevent its extensive clinical application. Curcumin high hydrophobicity of curcumin and limited water solubility are among the most important limitations. This poor solubility will result in low bioavailability due to its poor absorption into plasma and the target tissues. Curcumin also has rapid metabolism, which will significantly lower its bioavailability and shorten its half-life. Moreover, curcumin is photosensitive with limited chemical stability during manufacturing and storage. These limitations have been overcome by applying nanotechnology using several types of nanoparticles (NPs). This includes using NPs such as liposomes, niosomes, gold nanoparticles, and many others to improve the curcumin solubility and bioavailability. This review focuses on the different types of NPs investigated and the outcomes generated by their use in the most recent studies in this field. To follow the latest advances in the field of site-specific drug delivery using nanomaterials, an electronic databases search was conducted using PubMed, Google scholar and Scopus using the following keywords: lipid-based nanoparticles, curcumin delivery, niosomes, and liposomes.
姜黄素是从姜黄根茎中提取的一种天然成分，姜黄是一种有着4000多年药用历史的天然植物。姜黄的大多数治疗作用都归因于姜黄素，一种黄色提取物。由于其生物活性，如在关节炎、肝脏疾病、神经退行性疾病、肥胖症以及几种癌症中的应用，姜黄素受到了广泛关注。姜黄素的这些治疗活性大多与其抗氧化和抗炎作用有关。然而，姜黄素的临床应用受到一些限制，阻碍了其广泛的临床应用。姜黄素的高疏水性和有限的水溶性是最重要的限制因素之一。这种低溶解度会导致其生物利用度低，因为它难以吸收进入血浆和靶组织。姜黄素还具有快速代谢的特点，这将显著降低其生物利用度并缩短其半衰期。此外，姜黄素对光敏感，在制造和储存过程中化学稳定性有限。通过应用纳米技术使用几种类型的纳米颗粒（NPs）克服了这些限制。这包括使用脂质体、非离子型脂质体、金纳米颗粒等纳米颗粒来提高姜黄素的溶解度和生物利用度。本综述重点关注所研究的不同类型的纳米颗粒以及它们在该领域最新研究中的应用结果。为了跟踪使用纳米材料进行位点特异性药物递送领域的最新进展，使用PubMed、谷歌学术和Scopus进行了电子数据库搜索，使用了以下关键词：脂质基纳米颗粒、姜黄素递送、非离子型脂质体和脂质体。
