Guan Yanjie, Wang Yifei, Li Bo, Shen Kai, Li Quanfu, Ni Yingyin, Huang Lei
Department of Histoembryology, Genetics and Developmental Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Key Laboratory of Reproductive Medicine, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai, 200025, People's Republic of China.
Innovative Research Team of High-Level Local Universities in Shanghai, Shanghai, People's Republic of China.
Cancer Cell Int. 2021 Jul 5;21(1):350. doi: 10.1186/s12935-021-02065-w.
The mitochondrion is an organelle that plays a vital role in energy production, cytoplasmic protein degradation and cell death. Mitophagy is an autophagic procedure that specifically clears damaged mitochondria and maintains its homeostasis. Emerging evidence indicates that mitophagy is involved in many physiological processes, including cellular homeostasis, cellular differentiation and nerve protection. In this review, we describe the regulatory mechanisms of mitophagy in mammals and yeasts and highlight the recent advances relevant to its function in carcinogenesis and drug resistance. Finally, a section has been dedicated to describing the role of mitophagy in anticancer therapeutics, which is a new frontier that offers a precise and promising strategy.
线粒体是一种在能量产生、细胞质蛋白降解和细胞死亡中起关键作用的细胞器。线粒体自噬是一种自噬过程，可特异性清除受损的线粒体并维持其稳态。新出现的证据表明，线粒体自噬参与许多生理过程，包括细胞稳态、细胞分化和神经保护。在本综述中，我们描述了哺乳动物和酵母中线粒体自噬的调控机制，并强调了其在致癌作用和耐药性方面功能的最新进展。最后，专门有一部分描述了线粒体自噬在抗癌治疗中的作用，这是一个提供精确且有前景策略的新领域。
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