Eskander Georgette, Abdelhamid Sherihan G, Wahdan Sara A, Radwan Sara M
Postgraduate program, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Cell Death Discov. 2025 Feb 10;11(1):56. doi: 10.1038/s41420-025-02328-9.
The phenomenon of cell death has garnered significant scientific attention in recent years, emerging as a pivotal area of research. Recently, novel modalities of cellular death and the intricate interplay between them have been unveiled, offering insights into the pathogenesis of various diseases. This comprehensive review delves into the intricate molecular mechanisms, inducers, and inhibitors of the underlying prevalent forms of cell death, including apoptosis, autophagy, ferroptosis, necroptosis, mitophagy, and pyroptosis. Moreover, it elucidates the crosstalk and interconnection among the key pathways or molecular entities associated with these pathways, thereby paving the way for the identification of novel therapeutic targets, disease management strategies, and drug repurposing.
近年来，细胞死亡现象已引起科学界的广泛关注，成为一个关键的研究领域。最近，新的细胞死亡方式及其之间的复杂相互作用已被揭示，为各种疾病的发病机制提供了见解。这篇综述深入探讨了细胞死亡的潜在常见形式（包括凋亡、自噬、铁死亡、坏死性凋亡、线粒体自噬和焦亡）的复杂分子机制、诱导剂和抑制剂。此外，它还阐明了与这些途径相关的关键途径或分子实体之间的相互作用和联系，从而为确定新的治疗靶点、疾病管理策略和药物再利用铺平了道路。
