化疗诱导后小儿急性淋巴细胞白血病患者的临床特征和结局：来自巴勒斯坦的一项初步描述性相关性研究。
Clinical characteristics and outcomes of patients with pediatric acute lymphoblastic leukemia after induction of chemotherapy: a pilot descriptive correlational study from Palestine.
机构信息
Department of Physiology, Pharmacology and Toxicology, Faculty of Medicine and Health Sciences, An-Najah National University, New Campus, Building: 19, Office: 1340, P.O. Box 7, Nablus, Palestine.
An-Najah BioSciences Unit, Centre for Poisons Control, Chemical and Biological Analyses, An-Najah National University, Nablus, Palestine.
出版信息
BMC Res Notes. 2021 Jul 5;14(1):259. doi: 10.1186/s13104-021-05678-6.
OBJECTIVE
Pediatric acute lymphoblastic leukemia (ALL) is the most prevalent type of cancer among children. This study was conducted to describe and correlate the clinical characteristics and outcomes of treatment of patients with pediatric ALL in the main referral hospital in Palestine.
RESULTS
Complete data of 69 patients were included in this analysis. The majority (79.7%) of the patients had B-ALL phenotype. After induction chemotherapy, remission was experienced by the vast majority of the patients and 5 (7.2%) experienced relapses. Cytogenetics for patients with B-ALL phenotype indicated that 10 (18.2%) patients had t(12, 21) translocation, 5 (9.1%) had hyperdiploidy, 4 (7.3%) had t(1, 19) translocation, and 2 (3.6%) had t(9, 22) translocation. The initial white blood cells (p value < 0.001), absolute neutrophils (p value = 0.011), and hemoglobin (p value < 0.001) were significantly lower in patients with B-cell ALL. Platelet counts were significantly lower (p value = 0.012) in patients with splenomegaly and those with bleeding symptoms (p value = 0.008). Presence of palmar pollar was positively associated (p value = 0.035) with T-cell ALL. Presence of hepatomegaly was positively associated (p value < 0.001) with splenomegaly.
目的
小儿急性淋巴细胞白血病（ALL）是儿童中最常见的癌症类型。本研究旨在描述和分析巴勒斯坦主要转诊医院小儿 ALL 患者的临床特征和治疗结果。
结果
本分析纳入了 69 例患者的完整数据。大多数患者（79.7%）为 B-ALL 表型。诱导化疗后，绝大多数患者缓解，5 例（7.2%）复发。B-ALL 表型患者的细胞遗传学显示，10 例（18.2%）患者存在 t（12,21）易位，5 例（9.1%）存在超二倍体，4 例（7.3%）存在 t（1,19）易位，2 例（3.6%）存在 t（9,22）易位。B 细胞 ALL 患者的初始白细胞（p 值<0.001）、绝对中性粒细胞（p 值=0.011）和血红蛋白（p 值<0.001）明显较低。血小板计数在脾肿大和有出血症状的患者中明显较低（p 值=0.012）。掌跖红斑与 T 细胞 ALL 呈正相关（p 值=0.035）。肝肿大与脾肿大呈正相关（p 值<0.001）。
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