巴基斯坦某单一中心儿童急性淋巴细胞白血病的临床特征与细胞遗传学
Clinical Characteristics and Cytogenetics of Childhood Acute Lymphoblastic Leukemia in a Single Center in Pakistan.
作者信息
Tabassum Najia, Muhammad Sadia, Mirza Talat, Butt Zainab, Mansoor Neelum
机构信息
Ziauddin Medical College, Karachi, Pakistan.
Indus Hospital, Karachi, Pakistan.
出版信息
Glob Pediatr Health. 2024 Jul 27;11:2333794X241256863. doi: 10.1177/2333794X241256863. eCollection 2024.
This study aimed to find the association between clinical characteristics, cytogenetics, and post-induction outcomes of childhood acute lymphoblastic leukemia. The study was conducted at the Indus Hospital in Karachi. Initial total leukocyte count (TLC), cytogenetics, CNS status, and post-induction remission status were recorded. Out of 108 children diagnosed with ALL, 66 (61.1%) were male and 42 (38.9%) were female. The majority 90 (83.3%) had B-ALL. CNS1 status was observed in 76 (84.4%) B-ALL and 18 (88.9%) T-ALL. All T-ALL and 89 (98.8%) B-ALL achieved remission post-induction. In B-ALL, 50 (55.5%) had a normal diploid karyotype, and 22 (24.4%) had numerical abnormalities. No typical gene rearrangement was observed in 66 (73.3%), 11 (12.2%) had BCR::ABL1, 10 (11.1%) had ETV6::RUNX1 and 3 (3.3%) KMT2A on FISH. No significant difference was observed between cytogenetics and clinical characteristics ( > .05). The study provides valuable data on childhood acute lymphoblastic leukemia in the Pakistani population.
本研究旨在探寻儿童急性淋巴细胞白血病的临床特征、细胞遗传学与诱导缓解后结局之间的关联。该研究在卡拉奇的印度河医院开展。记录了初始全白细胞计数（TLC）、细胞遗传学、中枢神经系统（CNS）状态及诱导缓解后状态。在108例诊断为急性淋巴细胞白血病的儿童中，66例（61.1%）为男性，42例（38.9%）为女性。大多数90例（83.3%）为B系急性淋巴细胞白血病（B-ALL）。76例（84.4%）B-ALL和18例（88.9%）T系急性淋巴细胞白血病（T-ALL）观察到CNS1状态。所有T-ALL和89例（98.8%）B-ALL诱导缓解后达到缓解。在B-ALL中，50例（55.5%）有正常二倍体核型，22例（24.4%）有数目异常。荧光原位杂交（FISH）检测中，66例（73.3%）未观察到典型基因重排，11例（12.2%）有BCR::ABL1，10例（11.1%）有ETV6::RUNX1，3例（3.3%）有KMT2A。细胞遗传学与临床特征之间未观察到显著差异（P＞0.05）。该研究为巴基斯坦人群的儿童急性淋巴细胞白血病提供了有价值的数据。
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