Soucy Courtni, Bouchard Danielle R, Hrubeniuk Travis, Sénéchal Martin
Cardiometabolic Exercise & Lifestyle Laboratory, University of New Brunswick, Fredericton, NB, Canada.
Faculty of Kinesiology, University of New Brunswick, Fredericton, NB, Canada.
Support Care Cancer. 2022 Jan;30(1):69-76. doi: 10.1007/s00520-021-06394-4. Epub 2021 Jul 6.
To describe the variability during weekly performance on physical function tests during a 12-week individualized exercise program for patients with breast cancer and to test if the expected improvements in physical function surpass the minimally clinically important difference (MCID), after accounting for week-to-week variance.
Twenty-five participants, 19 years and older living with breast cancer within 2 years of their initial diagnosis, were recruited. Some participants were undergoing active treatment, while others completed their treatment. The intervention was an individualized exercise session twice a week, for 1 h each session, for a total of 12 weeks. Main outcomes tested included the 6-min walk test and chair stand test.
A significant average improvement was observed in the 6MWT (p < .01) and the chair stand test (p < .001) following the intervention. Individual confidence intervals were wide across all testing measures with only 28% and 8% of participants meeting or surpassing the MCID for the 6MWT and chair stand test, respectively.
Despite a significant improvement in physical function during the program, the majority of patients did not reach the MCID, which could be due to large variability resulting from treatment-related side effects or measurement error.
描述针对乳腺癌患者的12周个体化运动计划期间，每周进行身体功能测试时的变异性，并在考虑到周与周之间的差异后，测试身体功能的预期改善是否超过最小临床重要差异（MCID）。
招募了25名年龄在19岁及以上、在初次诊断后2年内患有乳腺癌的参与者。一些参与者正在接受积极治疗，而另一些人则已完成治疗。干预措施为每周两次个体化运动课程，每次课程1小时，共12周。测试的主要结果包括6分钟步行测试和从椅子上站起测试。
干预后，6分钟步行测试（p <.01）和从椅子上站起测试（p <.001）均观察到显著的平均改善。所有测试指标的个体置信区间都很宽，只有28%和8%的参与者分别达到或超过了6分钟步行测试和从椅子上站起测试的MCID。
尽管在该计划期间身体功能有显著改善，但大多数患者未达到MCID，这可能是由于与治疗相关的副作用或测量误差导致的较大变异性。
