前列腺素E2在尿路结石形成中的可能作用。

The possible role of prostaglandin E2 in urinary stone formation.

作者信息

Hirayama H, Ikegami K, Shimomura T, Soejima H, Yamamoto T

机构信息

Department of Urology, Kumamoto University Medical School, Japan.

出版信息

J Urol. 1988 Mar;139(3):549-51. doi: 10.1016/s0022-5347(17)42517-1.

DOI:10.1016/s0022-5347(17)42517-1

PMID:3422697

Abstract

To investigate the role of prostaglandin E2 in urinary stone formation, urinary prostaglandin E2 was measured by radioimmunoassay in 28 men with recurrent idiopathic urolithiasis (14 normocalciuric and 14 hypercalciuric patients) and 6 healthy male volunteers. Urinary prostaglandin E2 levels were significantly higher (p less than 0.01) in the hypercalciuric group than in the normocalciuric and healthy control groups, and they showed a positive correlation with urinary calcium excretion. Urinary prostaglandin E2 and calcium excretions in the hypercalciuric and normocalciuric groups were suppressed significantly by indomethacin. Creatinine clearance was not reduced by indomethacin. The results suggest that renal prostaglandin E2 may participate in calcium stone formation by regulating the renal tubular handling of calcium.

摘要

为研究前列腺素E2在尿路结石形成中的作用，采用放射免疫分析法测定了28例复发性特发性尿路结石男性患者（14例正常钙尿症患者和14例高钙尿症患者）及6名健康男性志愿者的尿前列腺素E2水平。高钙尿症组的尿前列腺素E2水平显著高于正常钙尿症组和健康对照组（p<0.01），且与尿钙排泄呈正相关。消炎痛可显著抑制高钙尿症组和正常钙尿症组的尿前列腺素E2及钙排泄。消炎痛未降低肌酐清除率。结果提示，肾前列腺素E2可能通过调节肾小管对钙的处理参与钙结石的形成。