Zhang Jingyan, Duan Yanwen, Zhu Xiangcheng, Yan Xiaohui
Xiangya International Academy of Translational Medicine, Central South University, Changsha 410013, Hunan, China.
Hunan Engineering Research Center of Combinatorial Biosynthesis and Natural Product Drug Discovery, Changsha 410011, Hunan, China.
Sheng Wu Gong Cheng Xue Bao. 2021 Jun 25;37(6):2147-2165. doi: 10.13345/j.cjb.210033.
Angucyclines/angucyclinones are a large group of polycyclic aromatic polyketides and their producers are widely distributed in nature. This family of natural products attracts great attention because of their diverse biological activities and unique chemical structures. With the development of synthetic biology and the exploitation of the actinomycetes from previously unexplored environments, angucyclines/angucyclinones-like natural products with new skeletons were continuously discovered, thus enriching the structural diversity of this family. In this review we summarize the new angucyclines/angucyclinones analogues discovered in the last decade (2010-2020) by using different strategies, such as changing cultivation conditions, genetic modification, genome mining, bioactivity-guided compound isolation, and fermentation of actinomycetes from underexplored environments. We also discuss the role of synthetic biology in the discovery and development of new compounds of the angucycline/angucyclinone family.
安古环素/安古环酮是一大类多环芳香聚酮化合物，其产生菌在自然界中广泛分布。这类天然产物因其多样的生物活性和独特的化学结构而备受关注。随着合成生物学的发展以及对以前未探索环境中的放线菌的开发利用，不断发现具有新骨架的类安古环素/安古环酮天然产物，从而丰富了该家族的结构多样性。在本综述中，我们总结了过去十年（2010 - 2020年）通过不同策略发现的新的安古环素/安古环酮类似物，这些策略包括改变培养条件、基因改造、基因组挖掘、生物活性导向的化合物分离以及对未充分探索环境中的放线菌进行发酵。我们还讨论了合成生物学在安古环素/安古环酮家族新化合物发现和开发中的作用。
